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Thromb Haemost 1981; 46(03): 621-622
DOI: 10.1055/s-0038-1653431
Original Article
Schattauer GmbH Stuttgart

Subunit A of Factor XIII Regulates Subunit B Plasma Concentration

F Rodeghiero
*   The Divisione di Ematologia, Ospedale Regionale di Vicenza, Italy
,
M Morbin
*   The Divisione di Ematologia, Ospedale Regionale di Vicenza, Italy
,
T Barbui
**   The Divisione di Ematologia, Ospedali Riuniti di Bergamo, Italy
› Author Affiliations
Further Information

Publication History

Received 13 January 1981

Accepted 28 July 1981

Publication Date:
05 July 2018 (online)

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Summary

Subunit a of Factor XIII is found absent in homozygotes and reduced in heterozygotes. Since a concomitant reduction of subunit b occurs in these cases, an interaction between the loci controlling the synthesis of the two subunits was suggested. However in the present study we have shown that the administration of subunit a in two totally devoid homozygotes produced an increase of subunit b, reaching the maximum concentration five days after infusion. This strongly suggests that subunit b plasma level is regulated on the subunit a plasma amount.

Keywords

Blood coagulation Factor XIII - Molecular subunits - Plasma level of Factor XIII
 

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