Development and Validation of a Practical Two-Step Prediction Model and Clinical Risk Score for Post-Thrombotic Syndrome

Elham E. Amin; Sander M. J. van Kuijk; Manuela A. Joore; Paolo Prandoni; Hugo ten Cate; Arina J. ten Cate-Hoek

doi:10.1055/s-0038-1655743

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2018; 118(07): 1242-1249
DOI: 10.1055/s-0038-1655743

New Technologies, Diagnostic Tools and Drugs

Georg Thieme Verlag KG Stuttgart · New York

Development and Validation of a Practical Two-Step Prediction Model and Clinical Risk Score for Post-Thrombotic Syndrome

Elham E. Amin

¹Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

²Department of Clinical Epidemiology and Medical Technology Assessment, School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands

,

Sander M. J. van Kuijk

²Department of Clinical Epidemiology and Medical Technology Assessment, School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands

,

Manuela A. Joore

²Department of Clinical Epidemiology and Medical Technology Assessment, School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands

,

Paolo Prandoni

³Arianna Foundation on Anticoagulation, Bologna, Italy

,

Hugo ten Cate

¹Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

⁴Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

,

Arina J. ten Cate-Hoek

¹Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

⁴Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

› Institutsangaben

Abstract

Background Post-thrombotic syndrome (PTS) is a common chronic consequence of deep vein thrombosis that affects the quality of life and is associated with substantial costs. In clinical practice, it is not possible to predict the individual patient risk. We develop and validate a practical two-step prediction tool for PTS in the acute and sub-acute phase of deep vein thrombosis.

Methods Multivariable regression modelling with data from two prospective cohorts in which 479 (derivation) and 1,107 (validation) consecutive patients with objectively confirmed deep vein thrombosis of the leg, from thrombosis outpatient clinic of Maastricht University Medical Centre, the Netherlands (derivation) and Padua University hospital in Italy (validation), were included. PTS was defined as a Villalta score of ≥ 5 at least 6 months after acute thrombosis.

Results Variables in the baseline model in the acute phase were: age, body mass index, sex, varicose veins, history of venous thrombosis, smoking status, provoked thrombosis and thrombus location. For the secondary model, the additional variable was residual vein obstruction. Optimism-corrected area under the receiver operating characteristic curves (AUCs) were 0.71 for the baseline model and 0.60 for the secondary model. Calibration plots showed well-calibrated predictions. External validation of the derived clinical risk scores was successful: AUC, 0.66 (95% confidence interval [CI], 0.63–0.70) and 0.64 (95% CI, 0.60–0.69).

Conclusion Individual risk for PTS in the acute phase of deep vein thrombosis can be predicted based on readily accessible baseline clinical and demographic characteristics. The individual risk in the sub-acute phase can be predicted with limited additional clinical characteristics.

Keywords

post-thrombotic syndrome - clinical risk score - prediction model - deep vein thrombosis - validation

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Referenzen

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