Platelet Factor 4 Complexed to Heparin Is the Target for Antibodies Generated in Heparin-Induced Thrombocytopenia

• References

• 1 Chong BH, Berndt MC. Heparin-induced thrombocytopenia. Blut 1989; 58: 53-57
• 2 Chong BH. Heparin-induced thrombocytopenia. Blood Rev 1988; 2: 108-114
• 3 Kelton JG. Heparin-induced thrombocytopenia. Haemostasis 1986; 16: 173-186
• 4 Horellou MH, Conard J, Lecrubier C, Samama M, Roque-d’Orbcastel O, de Fenoyl O, Di Maria G, Bernadou A. Persistent heparin induced thrombocytopenia despite therapy with low molecular weight heparin. Thromb Haemostas 1984; 51: 134
• 5 Miller M. Heparin-induced thrombocytopenia. Cleveland Clin J Med 1989; 56: 483-490
• 6 Amiral J, Bridey F, Dreyfus M, Vissac AM, Fressinaud E, Meyer D. Identification of PF4 as a target for antibodies generated in heparin-induced thrombocytopenia. Development of a diagnostic test. Thromb Haemostas 1991; 65: 865 (abstract)
• 7 Hermodson M, Schmer G, Kurachi K. Isolation, crystallization, and primary amino acid sequence of human platelet factor 4. J Biol Chem 1977; 252: 6276-6279