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Thromb Haemost 1992; 68(02): 111-114
DOI: 10.1055/s-0038-1656333
Original Article
Schattauer GmbH Stuttgart

Monocyte Tissue Factor Expression Induced by Plasmodium falciparum-Infected Erythrocytes

Gilles Pernod
1   Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France
2   Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
,
Benoît Polack
1   Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France
2   Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
,
François Peyron
3   Département de Parasitologie et Pathologie Exotique, Université Claude Bernard, Lyon, France
,
Annick Luisy
1   Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France
,
Lucien Kolodié
1   Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France
,
Pierre Ambroise-Thomas
2   Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
,
Ferrucio Santoro
2   Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
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Publikationsverlauf

Received 27. September 1991

Accepted after revision 21. Februar 1992

Publikationsdatum:
03. Juli 2018 (online)

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Summary

Monocytes are active elements of the host response against Plasmodium falciparum. They are able to express tissue factor and trigger the extrinsic pathway of blood coagulation the activation of which remained unclear in malaria. Our aim was to assess the tissue factor expression of purified blood monocytes stimulated by cultured Plasmodium falciparum-infected erythrocytes. Malaria parasite induced an early generation of tissue factor with a peak between 8 and 12 h of stimulation. Maximum expression was observed for parasitemia ranging from 1 to 2%. Plasmodium falciparum culture supernatants had the same effect showing the existence of a soluble factor able to induce the tissue factor expression. These data, demonstrating an activation of the tissue factor pathway by the malaria parasite, emphasize thrombin generation. Therefore, thrombin could participate in malaria pathology either in the microcirculatory blockade via platelet and fibrinogen activation or as a mitotic.

 

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