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Thromb Haemost 1979; 42(05): 1503-1507
DOI: 10.1055/s-0038-1657051
Original Article
Schattauer GmbH Stuttgart

Increased Plasma Fibrinogen and Platelet-Aggregates in Type II Hyperlipoproteinaemia

G D O Lowe
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
,
Maureen M Drummond
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
,
Jane L H C Third
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
,
W F Bremner
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
,
C D Forbes
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
,
C R M Prentice
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
,
T D V Lawrie
The University Departments of Medicine and Cardiology, Royal Infirmary, Glasgow, Great Britain
› Author Affiliations
Further Information

Publication History

Received 08 May 1979

Accepted 19 June 1979

Publication Date:
23 August 2018 (online)

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Summary

Plasma fibrinogen and platelet-aggregates (method of Wu and Hoak) were measured in 21 patients with familial Type II hyperlipoproteinaemia and 21 matched control subjects. Patients with hyperlipoproteinaemia had increased levels of fibrinogen and platelet- aggregates (p<0.01). Young patients with hyperlipoproteinaemia had prematurely high fibrinogen levels, and the normal rise in fibrinogen during adult life was abolished. There were no statistically significant correlations within the patient group between fibrinogen, platelet-aggregates, and plasma lipids. High fibrinogen and platelet-aggregate levels may play a part in the development of the premature arterial disease associated with Type II hyperlipoproteinaemia, or may be markers of arterial injury.

 

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