Thromboxane Synthetase Inhibition Results in Increased Platelet Sensitivity to Prostacyclin

Thromb Haemost 1982; 47(03): 294
DOI: 10.1055/s-0038-1657189

Letter to the Editor

Schattauer GmbH Stuttgart

Vittorio Bertelé

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy

,

Anna Falanga

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy

,

Maria Carla Roncaglioni

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy

,

Chiara Cerletti

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy

,

Giovanni de Gaetano

Istituto di Ricerche Farmacologiche, «Mario Negriu», Via Eritrea, 62, 20157 Milan, Italy

References
1 Bertelé V, Cerletti C, Schieppati A, Di Minno G, de Gaetano G. Inhibition of thromboxane synthetase does not necessarily prevent platelet aggregation. Lancet 1981; 1: 1057-1058
2 Bills TK, Smith JB, Silver MJ. Metabolism of [¹⁴C] arachidonic acid by human platelets. Biochim Biophys Acta 1976; 424: 303-314
3 Miller OV, Gorman RR. Evidence for distinct prostaglandin I₂ and D₂ receptors in human platelets. J Pharmacol Exp Ther 1979; 210: 134-140
4 de Gaetano G. Prostaglandin effects on platelets In: Abstracts, Prostaglandins in Cardiovascular and Thrombotic Disorders, Proc Symp Chicago. Illinois, May 7–9, 1981