Increased Tissue Thromboplastin Activity in Monocytes of Patients with Meningococcal Infection: Related to an Unfavourable Prognosis

B Østerud; T Flægstad

doi:10.1055/s-0038-1657303

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1983; 49(01): 005-007
DOI: 10.1055/s-0038-1657303

Original Article

Schattauer GmbH Stuttgart

Increased Tissue Thromboplastin Activity in Monocytes of Patients with Meningococcal Infection: Related to an Unfavourable Prognosis

B Østerud

The Institute of Medical Biology, University of Tromsø and Department of Pediatric, University Hospital of Tromsø, Tromsø, Norway

,

T Flægstad

The Institute of Medical Biology, University of Tromsø and Department of Pediatric, University Hospital of Tromsø, Tromsø, Norway

› Author Affiliations

Abstract

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Summary

In 16 patients, 13 with meningococcal infection and 3 suspected to have this infection, 8 patients were found to possess significant higher level of tissue thromboplastin activity of their monocytes isolated from the blood at the admission to the hospital than normal. Five of those 8 patients had an extremely high concentration, > 60-300 fold increase, and all these patients died. The exposed tissue thromboplastin activity on the surface of the endotoxin stimulated monocytes is probably the direct inducer of disseminated intravascular coagulation (DIC) in meningococcal infection.

Keywords

Tissue thromboplastin - Meningococcal infection - Monocyte - stimulation

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References

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