Download PDF
Thromb Haemost 1997; 78(01): 599-604
DOI: 10.1055/s-0038-1657596
Structure and mechanism of action of vitamin K-dependent gamrnt-ctrboxylase
Schattauer GmbH Stuttgart

Characterization of the ϒ-Glutamyl Carboxylase

Darrel W Stafford
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
,
S M Wu
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
,
Thomas B Stanley
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
,
Vasantha P Mutucumarana
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Price PA. Role of vitamin-K-dependent proteins in bone metabolism. [Review] Ann Rev Nutrition 1988; 8: 565-583
    CrossrefPubMedSearch in Google Scholar
  • 2 Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol 1993; 13 (08) 4976-4985
    CrossrefPubMedSearch in Google Scholar
  • 3 Stenflo J, Ferlund P, Egan W, Roepstorff P. Vitamin K dependent modifications of glutamic acid residues in prothrombin. Proc Nat Acad Sci USA 1974; 71 (07) 2730-2733
    CrossrefPubMedSearch in Google Scholar
  • 4 Nelsestuen GL, Zytkovicz TH, Howard JB. The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin. J Biol Chem 1974; 249 (19) 6347-6350
    CrossrefPubMedSearch in Google Scholar
  • 5 Magnusson S, Sottrup JensenL, Petersen TE, Morris HR, Dell A. Primary structure of the vitamin K-dependent part of prothrombin. FEBS Lett 1974; 44 (02) 189-193
    CrossrefPubMedSearch in Google Scholar
  • 6 Esmon CT, Sadowski JA, Suttie JW. A new carboxylation reaction. The vitamin K-dependent incorporation of H-14-C03-into prothrombin. J Biol Chem 1975; 250 (12) 4744-4748
    PubMedSearch in Google Scholar
  • 7 Suttie JW. Vitamin K-dependent carboxylase. [Review] Annu Rev Biochem 1985; 54: 459-477
    CrossrefPubMedSearch in Google Scholar
  • 8 Wu SM, Morris DP, Stafford DW. Identification and purification to near homogeneity of the vitamin K-dependent carboxylase. Proc Nat Acad Sci USA 1991; 88 (06) 2236-2240
    CrossrefPubMedSearch in Google Scholar
  • 9 Suttie JW, Hageman JM, Lehrman RS, Rich DH. Vitamin K-dependent carboxylase. Development of a peptide substrate. J Biol Chem 1976; 251 (18) 5827-5830
    PubMedSearch in Google Scholar
  • 10 de Metz M, Vermeer C, Soute BA, van SGJ, Slotboom AJ, Hemker HC. Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X. FEBS Lett 1981; 123 (02) 215-218
    CrossrefPubMedSearch in Google Scholar
  • 11 Pan LC, Price PA. The propeptide of rat bone gamma-carboxy-glutamic acid protein shares homology with other vitamin K-dependent protein precursors. Proc Nat Acad Sci USA 1985; 82 (18) 6109-6113
    CrossrefPubMedSearch in Google Scholar
  • 12 Knobloch JE, Suttie JW. Vitamin K-dependent carboxylase. Control of enzyme activity by the “propeptide” region of factor X. J Biol Chem 1987; 262 (32) 15334-15337
    PubMedSearch in Google Scholar
  • 13 Ulrich MM, Furie B, Jacobs MR, Vermeer C, Furie BC. Vitamin K-dependent carboxylation. A synthetic peptide based upon the gamma-carboxylation recognition site sequence of the prothrombin propeptide is an active substrate for the carboxylase in vitro. J Biol Chem 1988; 263 (20) 9697-9702
    PubMedSearch in Google Scholar
  • 14 Hubbard BR, Ulrich MM, Jacobs M. et al Vitamin K-dependent carboxylase: affinity purification from bovine liver by using a synthetic propeptide containing the gamma-carboxylation recognition site. Proc Nat Acad Sci USA 1989; 86 (18) 6893-6897
    CrossrefPubMedSearch in Google Scholar
  • 15 Wu SM, Morris DP, Stafford DW. Identification and purification to near homogeneity of the vitamin K-dependent carboxylase. Proc Nat Acad Sci USA 1991; 88 (06) 2236-2240
    CrossrefPubMedSearch in Google Scholar
  • 16 Berkner KL, Harbeck M, Lingenfelter S. et al. Purification and identification of bovine liver gamma-carboxylase. Proc Nat Acad Sci USA 1992; 89 (14) 6242-6246
    CrossrefPubMedSearch in Google Scholar
  • 17 Kaplan DJ, Jurka J, Solus JF, Duncan CH. Medium reiteration frequency repetitive sequences in the human genome. Nucleic Acids Res 1991; 19 (17) 4731-4738
    CrossrefPubMedSearch in Google Scholar
  • 18 Jurka J, Milosavljevic A. Reconstruction and analysis of human Alu genes. J Mol Evol 1991; 32 (02) 105-121
    CrossrefPubMedSearch in Google Scholar
  • 19 McCombie WR, Martin-Gallardo A, Gocayne JD. et al. Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4pl6.3. Nature Genetics 1992; 1: 348-353
    CrossrefPubMedSearch in Google Scholar
  • 20 De La Rosa J, Ostrowski J, Hiyniewicz MM. et al Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase. J Biol Chem 1995; 270 (37) 21860-21868
    CrossrefPubMedSearch in Google Scholar
  • 21 Penotti FE. Human DNA TATA boxes and transcription initiation sites. A statistical study. J Mol Biol 1990; 213 (01) 37-52
    CrossrefPubMedSearch in Google Scholar
  • 22 Wahle E, Keller W. The biochemistry of 3'-end cleavage and polyadenylation of messenger RNA precursors. Annu Rev Biochem 1992; 61: 419-440
    CrossrefPubMedSearch in Google Scholar
  • 23 Almenoff JS, Jurka J, Schoolnik GK. Induction of heat-stable enterotoxin receptor activity by a human Alu repeat. J Biol Chem 1994; 269 (24) 16610-16617
    PubMedSearch in Google Scholar
  • 24 Vansant G, Reynolds WF. The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element. Proc Nat Acad Sci USA 1995; 92 (18) 8229-8233
    CrossrefPubMedSearch in Google Scholar
  • 25 Chu K, Wu S-M, Stanley TB, Stafford DW, High KA. A mutation in the propeptide of factor IX leads to warfarin sensitivity by a novel mechanism. J Clin Invest 1996; 98 (07) 1619-1625
    CrossrefPubMedSearch in Google Scholar
  • 26 Soute BA, Ulrich MM, Vermeer C. Vitamin K-dependent carboxylase: increased efficiency of the carboxylation reaction. Thromb Haemo 1987; 57 (01) 77-81
    PubMedSearch in Google Scholar
  • 27 Soute BA, Ulrich MM, Watson AD, Maddison JE, Ebberink RH, Vermeer C. Congenital deficiency of all vitamin K-dependent blood coagulation factors due to a defective vitamin K-dependent carboxylase in Devon Rex cats. Thromb Haemo 1992; 68 (05) 521-525
    PubMedSearch in Google Scholar
  • 28 Jorgensen MJ, Cantor AB, Furie BC, Brown CL, Shoemaker CB, Furie B. Recognition site directing vitamin K-dependent gamma-carboxylation resides on the propeptide of factor IX. Cell 1987; 48 (02) 185-191
    CrossrefPubMedSearch in Google Scholar
  • 29 Foster DC, Rudinski MS, Schach BG. et al Propeptide of human protein C is necessary for gamma-carboxylation. Biochemistry 1987; 26 (22) 7003-70ll
    CrossrefPubMedSearch in Google Scholar
  • 30 Wu SM, Soute BA, Vermeer C, Stafford DW. In vitro gamma-carboxylation of a 59-residue recombinant peptide including the propeptide and the gamma-carboxyglutamic acid domain of coagulation factor IX. Effect of mutations near the propeptide cleavage site. J Biol Chem 1990; 265 (22) 13124-13129
    PubMedSearch in Google Scholar
  • 31 Morris DP, Stevens RD, Wright DJ, Stafford DW. Processive post-translational modification, vitamin K-dependent carboxylation of a peptide substrate. J Biol Chem 1995; 270 (51) 30498-30499
    PubMedSearch in Google Scholar