A Comparative Study Using Immunological and Biological Assays of the Haemostatic Responses to DDAVP Infusion Venous Occlusion and Exercise in Normal Men

C V Prowse; A Farrugia; F E Boulton; J Tucker; C A Ludlam; M McLaren; J J F Belch; C R M Prentice; J Dawes; I R MacGregor

doi:10.1055/s-0038-1661034

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1984; 51(01): 110-114
DOI: 10.1055/s-0038-1661034

Original Article

Schattauer GmbH Stuttgart

A Comparative Study Using Immunological and Biological Assays of the Haemostatic Responses to DDAVP Infusion Venous Occlusion and Exercise in Normal Men

C V Prowse

The Edinburgh and South-East Scotland Blood Transfusion Service Edinburgh, Great Britain

,

A Farrugia

The Edinburgh and South-East Scotland Blood Transfusion Service Edinburgh, Great Britain

,

F E Boulton

The Edinburgh and South-East Scotland Blood Transfusion Service Edinburgh, Great Britain

,

J Tucker

^*The Department of Haematology, Royal Infirmary, Edinburgh, Great Britain

,

C A Ludlam

^*The Department of Haematology, Royal Infirmary, Edinburgh, Great Britain

,

M McLaren

^**The Department of Medicine, Royal Infirmary, Glasgow, Great Britain

,

J J F Belch

^**The Department of Medicine, Royal Infirmary, Glasgow, Great Britain

,

C R M Prentice

^**The Department of Medicine, Royal Infirmary, Glasgow, Great Britain

,

J Dawes

^***The MRC/SNBTS Blood Components Assay Group, Forrest Road, Edinburgh, Great Britain

,

I R MacGregor

^****The Scottish National Blood Transfusion Service, Headquarters Laboratory, Forrest Road, Edinburgh, Great Britain

› Author Affiliations

Abstract

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Summary

In a group of six normal male volunteers, infusion of DDAVP, venous occlusion and exercise were shown to increase plasma levels of factor VIII and plasminogen activator, activity and antigen, to different extents and at differing rates. Any mechanisms suggested to explain release of these proteins by various stimuli should account for such differences.

All three stimuli could also increase plasma levels of prostacyclin metabolites, although this was only significant for high doses of DDAVP. Other potential endothelial markers, such as fibronectin and thrombospondin, showed no specific increase after any of the stimuli.

Key Words

Plasminogen activator - Factor VIII - DDAVP - Venous occlusion - Exercise

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References

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