The antithrombotic action of the highly effective synthetic thrombin inhibitor Nα-(2-naphthylsulfonylglycyl)-4-amidino-phenylalanine piperidide was studied in various models of experimental thrombosis in rats. Intravenous infusion of the thrombin inhibitor caused a dose-dependent inhibition or prevention of stasis-induced venous thrombosis, of arterial thrombosis after electrically-induced damage of the vessel wall and of thrombotic occlusion of an extracorporeal arterio-venous shunt.
Key words
Experimental models of thrombosis - Synthetic thrombin inhibitor - Antithrombotic action
