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Thromb Haemost 1986; 55(03): 314-317
DOI: 10.1055/s-0038-1661554
Original Article
Schattauer GmbH Stuttgart

Fibrinolytic Activity and Protein C in Preeclampsia

J Aznar
1   The Department of Clinical Pathology, Hospital de la Seguridad Social “La Fe”, Valencia, Spain
,
J Gilabert
2   The Department of Obstetrics and Gynecology, Hospital de la Seguridad Social “La Fe”, Valencia, Spain
,
A Estellés
3   The Research Center, Hospital de la Seguridad Social “La Fe”, Valencia, Spain
,
F España
3   The Research Center, Hospital de la Seguridad Social “La Fe”, Valencia, Spain
› Author Affiliations
Further Information

Publication History

Received 27 September 1985

Accepted after revision 04 March 1986

Publication Date:
18 July 2018 (online)

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Summary

Various parameters of the fibrinolytic system and antigenic and functional protein C and its inhibitor were studied during normal pregnancy and in patients with preeclampsia.

The fast acting tissue-type plasminogen activator inhibitor level was found to increase progressively during normal pregnancy. This increase was more evident in cases of severe preeclampsia (p<0.05). No variations were observed in protein C levels in normal pregnancies but a reduction in protein C level was noted in patients with severe preeclampsia (p<0.01). In preeclampsia, the protein C inhibitor level was higher than in normal pregnancy; it was also higher in normal pregnancy when compared to the control group.

Keywords

Pregnancy - Preeclampsia - Fibrinolytic activity - Protein C - t-PA inhibitor
 

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