Phosphorylation of Carboxylic Acids and Their Derivatives with P(O)–H Compounds Forming P(O)–C Bonds

Abstract

Herein, we highlight advances in the phosphorylation of readily available carboxylic acids and their derivatives forming synthetically important P(O)–sp³C, P(O)–sp²C, and P(O)–spC bonds, with an emphasis on the results demonstrated since 2010. This review examines the challenges associated with the use of this strategy for the synthesis of organophosphorus compounds and details advances in the design of catalytic systems that suppress these problems thus resulting in notable progress. Mechanistic details are discussed where available.

1 Introduction

2 Formation of P(O)–sp³C Bonds

3 Formation of P(O)–sp²C Bonds

4 Formation of P(O)–spC Bonds

5 Outlook and Conclusion

Key words

phosphorylation - carboxylic acids - decarboxylation - decarbonylation - cross coupling

Publication History

Received: 13 July 2020

Accepted after revision: 22 August 2020

Article published online:
30 September 2020

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