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Synthesis 2020; 52(12): 1773-1778
DOI: 10.1055/s-0040-1707989
DOI: 10.1055/s-0040-1707989
paper
A Convenient Synthesis of Amidines via Cycloaddition–Decarboxylation of Isocyanates and Nitrones
This work was financially supported by the talent plan of Jiangsu Normal University (16XLR013).Further Information
Publication History
Received: 07 January 2020
Accepted after revision: 17 February 2020
Publication Date:
09 March 2020 (online)
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Abstract
A base-promoted reaction between isocyanates and nitrones has been described, allowing an access to a variety of important functionalized amidines under mild reaction conditions. This strategy provides a convenient, effective, and scalable approach for the direct assembly of amidine compounds from simple starting materials in excellent yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707989.
- Supporting Information