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Homeopathy 2021; 110(02): 076-085
DOI: 10.1055/s-0040-1716369
Review Article

Homeopathy in Experimental Cancer Models: A Systematic Review

Andreza Pereira dos Santos
1   Research Center, Universidade Paulista, UNIP, Graduate Program in Environmental and Experimental Pathology, São Paulo, Brazil
,
Thayná Neves Cardoso
1   Research Center, Universidade Paulista, UNIP, Graduate Program in Environmental and Experimental Pathology, São Paulo, Brazil
,
Silvia Waisse
2   Pontifical Catholic University of São Paulo, PUC-SP, Graduate Program in History of Science, São Paulo, Brazil
,
Leoni Villano Bonamin 
1   Research Center, Universidade Paulista, UNIP, Graduate Program in Environmental and Experimental Pathology, São Paulo, Brazil
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Abstract

Background Complementary and alternative medicine, including homeopathy, is widely used to improve well-being among cancer patients and reduce adverse effects of conventional treatment. In contrast, there are few studies on the use of homeopathic medicines to treat the disease itself. Yet, evidence of possible effectiveness of homeopathic high dilutions in experimental cancer models has been published during the past 20 years.

Aim The aim of the study was to perform a systematic review of fundamental research studies on homeopathic high dilutions in cancer.

Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, we conducted a literature search in the database PubMed for original publications, from 2000 to 2018 and in English, on in vitro and in vivo experimental cancer models testing homeopathic high dilutions.

Results Twenty-three articles met the inclusion criteria—14 in vitro, eight in vivo, and one in vitro plus in vivo experimental models. Most studies were from India. Research prominently focused on cytotoxic effects involving apoptotic mechanisms. Intrinsic aspects of homeopathy should be considered in experimental designs to emphasize the specificity of such effects.

Conclusion Fundamental research of homeopathy in cancer is still at an early stage and has mainly been performed by a few groups of investigators. The results point to an interference of well-selected homeopathic medicines with cell cycle and apoptotic mechanisms in cancer cells. However, these findings still need independent reproduction.

Keywords

experimental oncology - high dilutions - methodological analysis

Highlights

• Effectiveness of homeopathic products on cancer has been experimentally tested since the early 2000s.


• A systematic review of these studies was performed using PRISMA methods.


• Cell cycle arrest and increase in apoptosis rate were the most reported findings.


• Methodological deficiencies were revealed among the studies.


• Recommendations for further studies are suggested.


Supplementary Material



Publication History

Received: 13 April 2020

Accepted: 15 June 2020

Article published online:
21 December 2020

© 2020. Faculty of Homeopathy. This article is published by Thieme.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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