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Synthesis 2022; 54(11): 2677-2686
DOI: 10.1055/s-0040-1719907
DOI: 10.1055/s-0040-1719907
paper
Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3-a]azines as Potential HSF1 Inductors
The research was supported by Ministry of Science and Higher Education of Russia, Research Project N 075-15-2020-795, local identifier 13.1902.21.0027.
Abstract
Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation.
Key words
azoloazine - hypervalent iodine(III) - cyclization - HSF1 inductors - heteroaromatic - metalloceneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1719907.
- Supporting Information
Publication History
Received: 29 November 2021
Accepted after revision: 04 February 2022
Article published online:
17 March 2022
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