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Synlett 2023; 34(07): 777-792
DOI: 10.1055/s-0042-1751421
DOI: 10.1055/s-0042-1751421
account
Chemical Synthesis and Catalysis in India
Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis
R.K. is thankful to the Haryana State Council for Science, Innovation and Technology (HSCSIT), DST Haryana, for a research grant (HSCSIT/R&D/163) and the J. C. Bose University of Science & Technology, YMCA, for a seed grant (R&D/SG/2020-21/166). F.V.S. is thankful to the Council of Scientific and Industrial Research (CSIR), New Delhi (02/(0330)/17-EMR-II). T.D. acknowledges support from the Japan Society for the Promotion of Science (JSPS), KAKENHI (19K05466), the Japan Science and Technology Agency (JST), CREST (JPMJCR20R1) and the Ritsumeikan Global Innovation Research Organization (R-GIRO).
Abstract
The Vilsmeier–Haack reaction has historically been a topic of significant interest to organic chemists, and it continues to attract considerable attention. The reaction itself provides a facile route towards a large number of aromatic and heteroaromatic systems. The Vilsmeier–Haack reagent, generated from amides and halides, is found to be very important in organic synthesis. This account highlights recent developments in the synthetic utility of the Vilsmeier–Haack reagent.
1 Introduction
2 Formylation
3 Formylation and Chlorination
4 Formylation and Acetylation
5 Chlorination
6 ortho-Formylation
7 Miscellaneous
8 Conclusions
Publication History
Received: 18 September 2022
Accepted after revision: 18 January 2023
Article published online:
28 February 2023
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