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CC BY 4.0 · Eur J Dent 2023; 17(01): 016-023
DOI: 10.1055/s-0042-1755625
Review Article

Potential Use of Hyperbaric Oxygen Therapy in Orthodontic Treatment: A Systematic Review of Animal Studies

Autor*innen

  • Yun Mukmin Akbar

    1   Doctoral Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia
    2   Department of Research Development, Indonesian Naval Dental Institute R.E. Martadinata, Jakarta, Indonesia

  • Ani Melani Maskoen

    3   Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia

  • Endah Mardiati

    4   Department of Orthodontics, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia

  • Ganesha Wandawa

    2   Department of Research Development, Indonesian Naval Dental Institute R.E. Martadinata, Jakarta, Indonesia

  • Arlette Suzy Setiawan 

    5   Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia

Funding None.
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Abstract

Understanding the fundamental principles of tooth movement could reduce the duration of treatment and achieve a stable outcome, resulting in patient satisfaction. Hyperbaric oxygen therapy was a modality in which a patient inhaled 100% O2 while subjected to high atmospheric pressure. Hyperbaric oxygen therapy facilitated the supply of oxygen to the human body's organs and tissues and served a variety of applications, including patient care and wound treatment. This review article aimed to describe animal studies of the potential effects of hyperbaric oxygen therapy in orthodontic therapy. It was conducted using a systematic literature review method, including searching PubMed and Google Scholar for publications relevant to the research topics. The search was filtered to include only research on orthodontic treatment and hyperbaric oxygen therapy and was published in any year. Articles that did not specify biological components of orthodontic tooth movement (OTM) were excluded. The Preferred Reporting Items identified the papers for the Systematic Reviews and Meta-Analyses (PRISMA) strategy, which resulted in the selection of 11 publications. Hyperbaric oxygen therapy affected parameters of biomarkers representing the clinical, molecular, and cellular biology of bone formation and resorption in periodontal tissues in responding to orthodontic physical forces, including alkaline phosphatase, collagen synthesis, osteoblast, osteoclast, osteocyte, type I collagen, vascular endothelial growth factor, osteocalcin, fibroblast, matrix metalloproteinase-8, transforming growth factor-β, partial pressure of oxygen, partial pressure of carbon dioxide, trabecular bone density, and tooth mobility. Hyperbaric oxygen therapy induced an inflammatory response to follow OTM events during active orthodontic therapy. Hyperbaric oxygen therapy might play a role in the tissue healing process during passive treatment. Nonetheless, additional research should be conducted to establish the efficacy of hyperbaric oxygen therapy in orthodontics.

Keywords

orthodontic treatment - orthodontic tooth movement - hyperbaric oxygen therapy - HBOT - animal studies

Authors' Contributions

All authors in this study admit to their involvement in the manuscript's creation stages. Y.M.A. conceived the ideas. Y.M.A., A.M.M., E.M., and G.W. gathered and processed data. Finally, Y.M.A. and A.S.S. helped finalize the manuscript.




Publikationsverlauf

Artikel online veröffentlicht:
11. Oktober 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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