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Pneumologie 2017; 71(06): 398-405
DOI: 10.1055/s-0043-102070
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

IgE und Anti-IgE bei Asthma: eine wechselvolle Geschichte

IgE and Anti-IgE in Asthma: A Chequered History
M. Lommatzsch
1   Abteilung für Pneumologie/Interdisziplinäre Internistische Intensivstation, Zentrum für Innere Medizin, Universität Rostock,
,
K. Geißler
1   Abteilung für Pneumologie/Interdisziplinäre Internistische Intensivstation, Zentrum für Innere Medizin, Universität Rostock,
,
K.-C. Bergmann
2   Allergie-Centrum der Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité – Campus Mitte, Berlin
,
J. Christian Virchow
1   Abteilung für Pneumologie/Interdisziplinäre Internistische Intensivstation, Zentrum für Innere Medizin, Universität Rostock,
› Author Affiliations
Further Information

Publication History

eingereicht 08 December 2016

akzeptiert nach Revision 28 March 2017

Publication Date:
26 June 2017 (online)

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Zusammenfassung

Es war ein langer und verschlungener Weg, der zur Entdeckung von Immunglobulin E (IgE) in den Jahren 1966 und 1967 führte. Wir befinden uns aktuell auf einem langen und verschlungenen Weg, um die immunologische Basis der klinischen Wirkung des Anti-IgE-Antikörpers Omalizumab bei Asthma zu begreifen. Möglicherweise profitieren beim Asthma (ähnlich wie bei der chronisch spontanen Urtikaria) Patienten auf unterschiedliche immunologische Art und Weise von einer Omalizumab-Therapie. Dieser Artikel gibt einen Überblick über die Historie der IgE-Entdeckung und die aktuellen Konzepte der Anti-IgE-Therapie bei Asthma.

Abstract

A long and winding road led to the discovery of immunoglobulin E (IgE) in 1966 and 1967. We are currently on a long and winding road to understand the immunologic basis of the clinical effects of the anti-IgE antibody omalizumab in asthma. It is possible that patients with asthma (as patients with chronic spontaneous urticaria) benefit in different immunologic ways from omalizumab treatment. This article reviews the history of IgE discovery and current concepts of anti-IgE therapy in asthma.

 

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