S2k-Leitlinie: Tuberkulose im Erwachsenenalter

Zusammenfassung

In Deutschland ist seit 2015 ein deutlicher Anstieg der gemeldeten Tuberkulosefälle zu verzeichnen. Zurückzuführen ist dieser vor allem auf die aktuell vermehrte Migration. Durch die niedrige Inzidenz in den vorhergehenden Jahren konzentriert sich die Erfahrung im Umgang mit Tuberkulose immer mehr auf spezialisierte Zentren. Pneumologen wie auch andere Fachbereiche sind nun aber wieder häufiger an der Behandlung einer Tuberkulose beteiligt, sodass Fachwissen zur Standardtherapie wie auch zu selteneren Therapiesituationen benötigt wird. Die aktuelle Leitlinie zur Diagnostik und Therapie, einschließlich Chemoprävention und -prophylaxe im Erwachsenenalter fasst den derzeitigen Wissensstand zusammen und passt die Empfehlungen an die Situation in Deutschland an. Realisiert wurde die AWMF S2k-Leitlinie durch das Deutsche Zentralkomitee zur Bekämpfung der Tuberkulose e. V. (DZK) im Auftrag der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. (DGP). Zur Behandlung der Tuberkulose im pädiatrischen Bereich wird in Kürze eine eigenständige Leitlinie der entsprechenden Fachgesellschaften veröffentlicht. Im Vergleich zu den Empfehlungen von 2012 sind eigenständige Kapitel zur Labordiagnostik und zum therapeutischen Medikamentenmanagement entstanden. Die Kapitel Mehrfachresistenzen gegen Medikamente der Standardtherapie, HIV-Koinfektion und die Übersicht der Arzneimittel wurden erweitert. Die umfangreiche Überarbeitung der Empfehlungen soll Ärzten und auch anderen Beschäftigten im Gesundheitswesen helfen, den aktuellen Herausforderungen im Umgang mit dem selten gewordenen Tuberkuloseerreger zu begegnen.

Abstract

Since 2015 a significant increase in tuberculosis cases is notified in Germany, mostly due to rising numbers of migrants connected to the recent refugee crisis. Because of the low incidence in previous years, knowledge on tuberculosis is more and more limited to specialized centers. However, lung specialist and healthcare workers of other fields have contact to an increasing number of tuberculosis patients. In this situation, guidance for the management of standard therapy and especially for uncommon situations will be essential.

This new guideline on tuberculosis in adults gives recommendations on diagnosis, treatment, prevention and prophylaxis. It provides a comprehensive overview over the current knowledge, adapted to the specific situation in Germany. The German Central Committee against Tuberculosis (DZK e. V.) realized this guideline on behalf of the German Respiratory Society (DGP). A specific guideline for tuberculosis in the pediatrics field will be published separately. Compared to the former recommendations of the year 2012, microbiological diagnostics and therapeutic drug management were given own sections. Chapters about the treatment of drug-resistant tuberculosis, tuberculosis in people living with HIV and pharmacological management were extended. This revised guideline aims to be a useful tool for practitioners and other health care providers to deal with the recent challenges of tuberculosis treatment in Germany.

• Literatur

• 1 World Health Organization. Guidelines for treatment of tuberculosis. Geneva: World Health Organization; 2010 4. Aufl.
• 2 World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis – 2011 update. Geneva: World Health Organization; 2011
• 3 Blumberg HM, Burman WJ, Chaisson RE. et al. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med 2003; 167: 603-662
• 4 National Collaborating Centre for Chronic Conditions and the Centre for Clinical Practice at NICE. Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control. NICE clinical guideline 117. London: National Institute for Health and Care Excellence NICE; 2011
• 5 Nahid P, Dorman SE, Alipanah N. et al. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis. Clin Infect Dis 2016; 63: e147-e195
• 6 Horsburgh Jr CR, Barry 3rd CE, Lange C. Treatment of Tuberculosis. N Engl J Med 2015; 373: 2149-2160
• 7 Yew WW, Lange C, Leung CC. Treatment of tuberculosis: update 2010. Eur Respir J 2011; 37: 441-462
• 8 Forßbohm M, Haas W. Leitfaden zur Übermittlung von Fallberichten zur Tuberkulose. Berlin: Robert-Koch-Institut; 2004
• 9 Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose (DZK). Tuberkulosescreening bei Schwangeren im Kontext von § 36 (4) Infektionsschutzgesetz (IfSG). Pneumologie 2016; 70: 777-780
• 10 Brodhun B, Altmann D, Hauer B. et al. Bericht zur Epidemiologie der Tuberkulose in Deutschland für 2014. Berlin: Robert Koch-Institut; 2015
• 11 World Health Organization. Companion Handbook to the WHO Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis. Geneva: World Health Organization; 2014
• 12 World Health Organization. WHO treatment guidelines for drug-resistant tuberculosis, 2016 update. Geneva: World Health Organization; 2016
• 13 Weiner M, Burman W, Luo CC. et al. Effects of rifampin and multidrug resistance gene polymorphism on concentrations of moxifloxacin. Antimicrob Agents Chemother 2007; 51: 2861-2866
• 14 Nijland HM, Ruslami R, Suroto AJ. et al. Rifampicin reduces plasma concentrations of moxifloxacin in patients with tuberculosis. Clin Infect Dis 2007; 45: 1001-1007
• 15 Alsultan A, Peloquin CA. Therapeutic drug monitoring in the treatment of tuberculosis: an update. Drugs 2014; 74: 839-854
• 16 Milburn H, Ashman N, Davies P. et al. Guidelines for the prevention and management of Mycobacterium tuberculosis infection and disease in adult patients with chronic kidney disease. Thorax 2010; 65: 557-570
• 17 Milburn HJ. How should we treat tuberculosis in adult patients with chronic kidney disease? Key messages from the British Thoracic Society Guidelines. Pol Arch Med Wewn 2010; 120: 417-422
• 18 Grim SA, Layden JE, Roth P. et al. Latent tuberculosis in kidney and liver transplant patients: a review of treatment practices and outcomes. Transpl Infect Dis 2015; 17: 768-777
• 19 Bumbacea D, Arend SM, Eyuboglu F. et al. The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement. Eur Respir J 2012; 40: 990-1013
• 20 Solovic I, Sester M, Gomez-Reino JJ. et al. The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement. Eur Respir J 2010; 36: 1185-1206
• 21 Diel R, Hauer B, Loddenkemper R. et al. Empfehlungen für das Tuberkulosescreening vor Gabe von TNF-α-Inhibitoren bei rheumatischen Erkrankungen. Pneumologie 2009; 63: 329-334
• 22 Wallis RS, van Vuuren C, Potgieter S. Adalimumab treatment of life-threatening tuberculosis. Clin Infect Dis 2009; 48: 1429-1432
• 23 Cantini F, Prignano F, Goletti D. Restarting biologics and management of patients with flares of inflammatory rheumatic disorders or psoriasis during active tuberculosis treatment. J Rheumatol Suppl 2014; 91: 78-82
• 24 Suh YS, Kwok SK, Ju JH. et al. Safe re-administration of tumor necrosis factor-alpha (TNFalpha) inhibitors in patients with rheumatoid arthritis or ankylosing spondylitis who developed active tuberculosis on previous anti-TNFalpha therapy. J Korean Med Sci 2014; 29: 38-42
• 25 Kim YJ, Kim YG, Shim TS. et al. Safety of resuming tumour necrosis factor inhibitors in patients who developed tuberculosis as a complication of previous TNF inhibitors. Rheumatology (Oxford) 2014; 53: 1477-1481
• 26 Hong Kong Chest Service. A controlled clinical comparison of 6 and 8 month of antituberculosis chemotherapy in the treatment of patients with silicotuberculosis in Hong Kong. Am Rev Respir Dis 1991; 143: 262-267
• 27 Mnyani CN, McIntyre JA. Tuberculosis in pregnancy. BJOG 2011; 118: 226-231
• 28 Nhan-Chang CL, Jones TB. Tuberculosis in pregnancy. Clin Obstet Gynecol 2010; 53: 311-321
• 29 Snider DE, Powell KE. Should woman taking antituberculous drugs breast-feed?. Arch Intern Med 1984; 144: 589-590
• 30 Davies PD. Tuberculosis in the elderly. J Antimicrobiol Chemother 1994; 34: A93-A100
• 31 Schaberg T, Rebhan K, Lode H. Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis. Eur Respir J 1996; 9: 2026-2030
• 32 Saukkonen JJ, Cohn DL, Jasmer RM. et al. An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med 2006; 174: 935-952
• 33 Jong E, Conradie F, Berhanu R. et al. Consensus statement: Management of drug-induced liver injury in HIV-positive patients treated for TB. Southern African Journal of HIV Medicine 2013; 14: 113
• 34 Thompson NP, Caplin ME, Hamilton MI. et al. Anti-tuberculous medication and the liver: dangers and recommendations in management. Eur Respir J 1995; 8: 1384-1388
• 35 Joint Tuberculosis Committee of the British Thoracic Society. Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998. Thorax 1998; 53: 536-548
• 36 Kopanoff DE, Snider DE, Caras GJ. Isoniazid-related hepatitis: a U.S. Public Health Service cooperative surveillance study. Am Rev Respir Dis 1978; 117: 991-1001
• 37 Centers for Disease Control and Prevention. Update: adverse event data and revised American Thoracic Society/CDC recommendations against the use of rifampin and pyrazinamide for treatment of latent tuberculosis infection. MMWR 2003; 52: 735-739
• 38 Kobashi Y, Abe T, Shigeto E. et al. Desensitization therapy for allergic reactions to antituberculous drugs. Intern Med 2010; 49: 2297-2301
• 39 Grosset J, Leventis S. Adverse effects of rifampin. Rev Infect Dis 1983; 5 (Suppl. 03) S440-S450
• 40 Keeping JA, Searle CW. Optic neuritis following isoniazid therapy. Lancet 1955; 269: 278
• 41 Snider Jr DE. Pyridoxine supplementation during isoniazid therapy. Tubercle 1980; 61: 191-196
• 42 Helgren ME, Cliffer KD, Torrento K. et al. Neurotrophin-3 administration attenuates deficits of pyridoxine-induced large-fiber sensory neuropathy. J Neurosci 1997; 17: 372-382
• 43 Chen HY, Albertson TE, Olson KR. Treatment of drug-induced seizures. British journal of clinical pharmacology 2016; 81: 412-419
• 44 Doherty AM, Kelly J, McDonald C. et al. A review of the interplay between tuberculosis and mental health. Gen Hosp Psychiatry 2013; 35: 398-406
• 45 Bruguerolle B. Chronopharmacokinetics. Current status. Clin Pharmacokinet 1998; 35: 83-94
• 46 Ferrer J. Pleural tuberculosis. Eur Respir J 1997; 10: 942-947
• 47 Wyser C, Walzl G, Smedema JP. et al. Corticosteroids in the treatment of tuberculous pleurisy. A double-blind, placebo-controlled, randomized study. Chest 1996; 110: 333-338
• 48 Evans DJ. The use of adjunctive corticosteroids in the treatment of pericardial, pleural and meningeal tuberculosis: do they improve outcome?. Respir Med 2008; 102: 793-800
• 49 Griffith DE, Aksamit T, Brown-Elliott BA. et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007; 175: 367-416
• 50 Sellar RS, Corbett EL, DʼSa S. et al. Treatment for lymph node tuberculosis. BMJ 2010; 340: c63
• 51 Cek M, Lenk S, Naber KG. et al. EAU guidelines for the management of genitourinary tuberculosis. Eur Urol 2005; 48: 353-362
• 52 Almadi MA, Ghosh S, Aljebreen AM. Differentiating intestinal tuberculosis from Crohn's disease: a diagnostic challenge. Am J Gastroenterol 2009; 104: 1003-1012
• 53 Klimach OE, Ormerod LP. Gastrointestinal tuberculosis: a retrospective review of 109 cases in a district general hospital. QJMed 1985; 56: 569-578
• 54 Tan KK, Chen K, Sim R. The spectrum of abdominal tuberculosis in a developed country: a single institution's experience over 7 years. J Gastrointest Surg 2009; 13: 142-147
• 55 Syed FF, Mayosi BM. A modern approach to tuberculous pericarditis. Prog Cardiovasc Dis 2007; 50: 218-236
• 56 Mayosi Bongani M. Interventions for treating tuberculous pericarditis. Cochrane Database of Systematic Reviews 2002; CD000526
• 57 Nau R, Prange HW, Menck S. et al. Penetration of rifampicin into the cerebrospinal fluid of adults with uninflamed meninges. J Antimicrob Chemother 1992; 29: 719-724
• 58 Nau R, Sorgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev 2010; 23: 858-883
• 59 Donald PR. The chemotherapy of tuberculous meningitis in children and adults. Tuberculosis(Edinb) 2010; 90: 375-392
• 60 Donald PR. Cerebrospinal fluid concentrations of antituberculosis agents in adults and children. Tuberculosis (Edinb) 2010; 90: 279-292
• 61 Thwaites G, Fisher M, Hemingway C. et al. British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect 2009; 59: 167-187
• 62 Prasad K, Singh MB. Corticosteroids for managing tuberculous meningitis. CochraneDatabaseSystRev 2008;
• 63 Weiss T, Schonfeld N, Bettermann G. et al. In vitro susceptibility of Mycobacterium bovis against moxifloxacin. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 1562
• 64 Babjuk M, Burger M, Zigeuner R. et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013. Eur Urol 2013; 64: 639-653
• 65 Rischmann P, Desgrandchamps F, Malavaud B. et al. BCG intravesical instillations: recommendations for side-effects management. Eur Urol 2000; 37 (Suppl. 01) 33-36
• 66 Witjes F, Palou J, Soloway M. et al. Clinical Practice Recommendations for the Prevention and Management of Intravesical Therapy–Associated Adverse Events. European Urology supplements 2008; 7: 667-674
• 67 Durek C, Rusch-Gerdes S, Jocham D. et al. Interference of modern antibacterials with bacillus Calmette-Guerin viability. J Urol 1999; 162: 1959-1962
• 68 Lamm DL. Complications of bacillus Calmette-Guerin immunotherapy. Urol Clin North Am 1992; 19: 565-572
• 69 Lamm DL, van der Meijden PM, Morales A. et al. Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer. J Urol 1992; 147: 596-600
• 70 Perez-Jacoiste Asin MA, Fernandez-Ruiz M, Lopez-Medrano F. et al. Bacillus Calmette-Guerin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature. Medicine 2014; 93: 236-254
• 71 Durek C, Jurczok A, Werner H. et al. Optimal treatment of systemic bacillus Calmette-Guerin infection: investigations in an animal model. J Urol 2002; 168: 826-831
• 72 Bohle A, Brandau S. Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. J Urol 2003; 170: 964-969
• 73 Obaid S, Weil AG, Rahme R. et al. Mycobacterium bovis spondylodiscitis after intravesical Bacillus Calmette-Guerin therapy. Surgical neurology international 2011; 2: 162
• 74 Vogl M. Assessing DRG cost accounting with respect to resource allocation and tariff calculation: the case of Germany. Health Econ Rev 2012; 2: 15
• 75 Diel R, Rutz S, Castell S. et al. Tuberculosis: cost of illness in Germany. Eur Respir J 2012; 40: 143-151
• 76 Diel R, Nienhaus A, Lampenius N. et al. Cost of multi drug resistance tuberculosis in Germany. Respir Med 2014; 108: 1677-1687
• 77 Diel R, Hittel N, Schaberg T. Cost effectiveness of treating multi-drug resistant tuberculosis by adding Deltyba™ to background regimens in Germany. Respir Med 2015; 109: 632-641
• 78 Schwabe U, Paffrath D. Arzneiverordnungs-Report 2015. 1. Aufl. Berlin-Heidelberg: Springer-Verlag; 2015
• 79 Lungenliga Schweiz. Tuberkulose in der Schweiz – Leitfaden für Fachpersonen des Gesundheitswesens. Bern: Lungenliga Schweiz; 2014
• 80 Richter E, Beer J, Diel R. et al. Tuberkulose Mykobakteriose. In: Podbielski A, Mauch H, Herrmann M. et al. Mikrobiologisch-infektiologische Qualitätsstandards (MIQ) 05. 2. Aufl. München und Jena: Urban & Fischer/Elsevier; 2010
• 81 DIN 58943-4 Beiblatt 1: 2011-03. Medizinische Mikrobiologie – Tuberkulosediagnostik – Teil 4: Primärproben zur Tuberkulose- und Mykobakteriosediagnostik – Qualitative und quantitative Anforderungen, Gewinnung, Transport und Aufbewahrung. Berlin: Beuth Verlag; 2011
• 82 Wildemann B, Oschmann P, Reiber H. Neurologische Labordiagnostik. Stuttgart: Thieme; 2006
• 83 Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci 2001; 184: 101-122
• 84 Malekmohammad M, Marjani M, Tabarsi P. et al. Diagnostic yield of post-bronchoscopy sputum smear in pulmonary tuberculosis. Scand J Infect Dis 2012; 44: 369-373
• 85 Bodal VK, Bal MS, Bhagat S. et al. Fluorescent microscopy and Ziehl-Neelsen staining of bronchoalveolar lavage, bronchial washings, bronchoscopic brushing and post bronchoscopic sputum along with cytological examination in cases of suspected tuberculosis. Indian J Pathol Microbiol 2015; 58: 443-447
• 86 DIN 58943-32:2015-05. Medizinische Mikrobiologie – Tuberkulosediagnostik – Teil 32: Mikroskopische Methoden zum Nachweis von Mykobakterien. Berlin: Beuth-Verlag; 2015
• 87 Ziegler R, Just HM, Castell S. et al. Infektionsprävention bei Tuberkulose – Empfehlungen des DZK. Pneumologie 2012; 66: 269-282
• 88 Diel R, Loytved G, Nienhaus A. et al. Neue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose. Pneumologie 2011; 65: 359-378
• 89 Pfyffer G. Mycobacterium: general characteristics, laboratory detection and staining procedures. In: Jorgensen M, Pfaller M, Carroll K. et al., Hrsg. Manual of Clinical Microbiology. Washington: ASM Press; 2015: 536-569
• 90 DIN 58943-3:2011-03. Medizinische Mikrobiologie – Tuberkulosediagnostik – Teil 3: Kulturelle Methoden zum Nachweis von Mykobakterien. Berlin: Beuth-Verlag; 2011
• 91 Palomino JC. Molecular detection, identification and drug resistance detection in Mycobacterium tuberculosis. FEMS Immunol Med Microbiol 2009; 56: 103-111
• 92 World Health Organization. Automated Real-Time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB/RIF Assay for the Diagnosis of Pulmonary and Extrapulmonary TB in Adults and Children: Policy Update. Geneva: World Health Organization; 2013
• 93 Rigouts L, Gumusboga M, de Rijk WB. et al. Rifampin resistance missed in automated liquid culture system for Mycobacterium tuberculosis isolates with specific rpoB mutations. J Clin Microbiol 2013; 51: 2641-2645
• 94 Andres S, Hillemann D, Rusch-Gerdes S. et al. Occurrence of rpoB mutations in isoniazid-resistant but rifampin-susceptible Mycobacterium tuberculosis isolates from Germany. Antimicrob Agents Chemother 2014; 58: 590-592
• 95 Williamson DA, Roberts SA, Bower JE. et al. Clinical failures associated with rpoB mutations in phenotypically occult multidrug-resistant Mycobacterium tuberculosis. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 216-220
• 96 Ho J, Jelfs P, Sintchencko V. Phenotypically occult multidrug-resistant Mycobacterium tuberculosis: dilemmas in diagnosis and treatment. J Antimicrob Chemother 2013; 68: 2915-2920
• 97 Van Deun A, Aung KJ, Hossain A. et al. Disputed rpoB mutations can frequently cause important rifampicin resistance among new tuberculosis patients. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2015; 19: 185-190
• 98 Ling DI, Zwerling AA, Pai M. GenoType MTBDR assays for the diagnosis of multidrug-resistant tuberculosis: a meta-analysis. Eur Respir J 2008; 32: 1165-1174
• 99 Nathavitharana RR, Hillemann D, Schumacher SG. et al. Multicenter Noninferiority Evaluation of Hain GenoType MTBDRplus Version 2 and Nipro NTM+MDRTB Line Probe Assays for Detection of Rifampin and Isoniazid Resistance. J Clin Microbiol 2016; 54: 1624-1630
• 100 World Health Organization. The use of molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs: Policy Guidance. Geneva: World Health Organization; 2016
• 101 Ritter C, Lucke K, Sirgel FA. et al. Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains. J Clin Microbiol 2014; 52: 940-946
• 102 DIN 58943-8:2009-04. Medizinische Mikrobiologie – Tuberkulosediagnostik – Teil 8: Empfindlichkeitsprüfung von Tuberkulosebakterien gegen Chemotherapeutika. Berlin: Beuth-Verlag; 2009
• 103 Horne DJ, Pinto LM, Arentz M. et al. Diagnostic accuracy and reproducibility of WHO-endorsed phenotypic drug susceptibility testing methods for first-line and second-line antituberculosis drugs. J Clin Microbiol 2013; 51: 393-401
• 104 World Health Organization. Updated interim critical concentrations for first-line and second-line DS. Im Internet: http://www.stoptb.org/wg/gli/assets/documents/Updated%20critical%20concentration%20table_1st%20and%202nd%20line%20drugs.pdf
• 105 Torrea G, Coeck N, Desmaretz C. et al. Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system. J Antimicrob Chemother 2015; 70: 2300-2305
• 106 Keller PM, Homke R, Ritter C. et al. Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST. Antimicrob Agents Chemother 2015; 59: 4352-4355
• 107 Stinson K, Kurepina N, Venter A. et al. MIC of Delamanid (OPC-67683) against Mycobacterium tuberculosis Clinical Isolates and a Proposed Critical Concentration. Antimicrob Agents Chemother 2016; 60: 3316-3322
• 108 Fenner L, Egger M, Bodmer T. et al. Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 2012; 56: 3047-3053
• 109 Otto-Knapp R, Vesenbeckh S, Schonfeld N. et al. Isoniazid minimal inhibitory concentrations of tuberculosis strains with katG mutation. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2016; 20: 1275-1276
• 110 Vilcheze C, Jacobs WR Jr. Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities. Microbiol Spectr 2014; 2
• 111 Ramirez-Busby SM, Valafar F. Systematic review of mutations in pyrazinamidase associated with pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates. Antimicrob Agents Chemother 2015; 59: 5267-5277
• 112 Farhat MR, Jacobson KR, Franke MF. et al. Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis. J Clin Microbiol 2016; 54: 727-733
• 113 Avalos E, Catanzaro D, Catanzaro A. et al. Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review. PLoS One 2015; 10: e0120470
• 114 Malinga L, Brand J, Olorunju S. et al. Molecular analysis of genetic mutations among cross-resistant second-line injectable drugs reveals a new resistant mutation in Mycobacterium tuberculosis. Diagn Microbiol Infect Dis 2016; 85: 433-437
• 115 Lee RS, Behr MA. The implications of whole-genome sequencing in the control of tuberculosis. Ther Adv Infect Dis 2016; 3: 47-62
• 116 Mack U, Migliori GB, Sester M. et al. LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. Eur Respir J 2009; 33: 956-973
• 117 Lange C, Mandalakas A, Kalsdorf B. et al. Clinical Application of Interferon-γ Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence. Pathog and Immun 2017; 1: 308-329
• 118 Diel R, Loddenkemper R, Zellweger J-P. et al. Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination. Eur Respir J 2013; 42: 785-801
• 119 Ferebee SH. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibliotheca Tuberculosea 1970; 26: 28-106
• 120 Parrish NM, Dick JD, Bishai WR. Mechanisms of latency in Mycobacterium tuberculosis. Trends Microbiol 1998; 6: 107-112
• 121 Sester M, van Leth F, Bruchfeld J. et al. Risk assessment of tuberculosis in immunocompromised patients. A TBNET study. Am J Respir Crit Care Med 2014; 190: 1168-1176
• 122 Cantini F, Nannini C, Niccoli L. et al. Guidance for the management of patients with latent tuberculosis infection requiring biologic therapy in rheumatology and dermatology clinical practice. Autoimmun Rev 2015; 14: 503-509
• 123 Barniol J, Niemann S, Louis VR. et al. Transmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations. BMC infect dis 2009; 9: 197
• 124 Ford CB, Lin PL, Chase MR. et al. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature genetics 2011; 43: 482-486
• 125 Colangeli R, Arcus VL, Cursons RT. et al. Whole genome sequencing of Mycobacterium tuberculosis reveals slow growth and low mutation rates during latent infections in humans. PLoS One 2014; 9: e91024
• 126 Comstock GW. How much isoniazid is needed for prevention of tuberculosis among immunocompetent adults?. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1999; 3: 847-850
• 127 Getahun H, Matteelli A, Abubakar I. et al. Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries. Eur Respir J 2015; 46: 1563-1576
• 128 Stagg HR, Zenner D, Harris RJ. et al. Treatment of latent tuberculosis infection: a network meta-analysis. Ann Intern Med 2014; 161: 419-428
• 129 Smieja MJ, Marchetti CA, Cook DJ. et al. Isoniazid for preventing tuberculosis in non-HIV infected persons. The Cochrane database of systematic reviews 2000; CD000171.pub3: CD001363
• 130 Akolo C, Adetifa I, Shepperd S. et al. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev 2010; CD000171.pub3
• 131 Sester M, van Crevel R, Leth F. et al. Numbers needed to treat to prevent tuberculosis. Eur Respir J 2015; 46: 1836-1838
• 132 Horwitz O, Payne PG, Wilbek E. Epidemiological basis of tuberculosis eradication. 4. The isoniazid trial in Greenland. Bulletin of the World Health Organization 1966; 35: 509-526
• 133 Comstock GW, Ferebee SH, Hammes LM. A controlled trial of community-wide isoniazid prophylaxis in Alaska. Am Rev Respir Dis 1967; 95: 935-943
• 134 Comstock GW, Baum C, Snider DE. Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies. Am Rev Respir Dis 1979; 119: 827-830
• 135 Johnson JL, Okwera A, Hom DL. et al. Duration of efficacy of treatment of latent tuberculosis infection in HIV-infected adults. AIDS (London, England) 2001; 15: 2137-2147
• 136 Elzi L, Schlegel M, Weber R. et al. Reducing tuberculosis incidence by tuberculin skin testing, preventive treatment, and antiretroviral therapy in an area of low tuberculosis transmission. Clin Infect Dis 2007; 44: 94-102
• 137 European Centre for Disease Prevention and Control. Management of contacts of MDR TB and XDR TB patients. Stockholm: ECDC; 2012
• 138 Centers for Disease Control and Prevention. Latent Tuberculosis Infection: A Guide For Primary Health Care Providers. Atlanta: CDC; 2013
• 139 Leung CC, Rieder HL, Lange C. et al. Treatment of latent infection with Mycobacterium tuberculosis: update 2010. Eur Respir J 2011; 37: 690-711
• 140 American Thoracic Society/CDC. Targeted tuberculin testing and treatment of latent tuberculosis infection. MMWR Recomm Rep 2000; 49: 1-51
• 141 Ziakas PD, Mylonakis E. 4 months of rifampin compared with 9 months of isoniazid for the management of latent tuberculosis infection: a meta-analysis and cost-effectiveness study that focuses on compliance and liver toxicity. Clin Infect Dis 2009; 49: 1883-1889
• 142 Menzies D, Long R, Trajman A. et al. Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection: a randomized trial. Ann Intern Med 2008; 149: 689-697
• 143 Aspler A, Long R, Trajman A. et al. Impact of treatment completion, intolerance and adverse events on health system costs in a randomised trial of 4 months rifampin or 9 months isoniazid for latent TB. Thorax 2010; 65: 582-587
• 144 Ena J, Valls V. Short-course therapy with rifampin plus isoniazid, compared with standard therapy with isoniazid, for latent tuberculosis infection: a meta-analysis. Clin Infect Dis 2005; 40: 670-676
• 145 Centers for Disease Control and Prevention. Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society. MMWR Recomm Rep 2000; 49: 1-51
• 146 Bothamley G. Drug treatment for tuberculosis during pregnancy: safety considerations. Drug Saf 2001; 24: 553-565
• 147 Malhame I, Cormier M, Sugarman J. et al. Latent Tuberculosis in Pregnancy: A Systematic Review. PLoS One 2016; 11: e0154825
• 148 Seidler A, Nienhaus A, Diel R. Review of epidemiological studies on the occupational risk of tuberculosis in low-incidence areas. Respiration 2005; 72: 431-446
• 149 Diel R, Loddenkemper R, Nienhaus A. Predictive value of interferon-gamma release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis. Chest 2012; 142: 63-75
• 150 Nienhaus A, Schablon A, Bacle CL. et al. Evaluation of the interferon-gamma release assay in healthcare workers. Int Arch Occup Environ Health 2008; 81: 295-300
• 151 Schablon A, Nienhaus A, Ringshausen FC. et al. Occupational screening for tuberculosis and the use of a borderline zone for interpretation of the IGRA in German healthcare workers. PloS one 2014; 9: e115322
• 152 Torres Costa J, Silva R, Ringshausen FC. et al. Screening for tuberculosis and prediction of disease in Portuguese healthcare workers. J Occup Med Toxicol 2011; 6: 19
• 153 Schaberg T, Bauer T, Castell S. et al. Empfehlungen zur Therapie, Chemoprävention und Chemoprophylaxe der Tuberkulose im Erwachsenen- und Kindesalter. Pneumologie 2012; 66: 133-171
• 154 Magdorf K, Bialek R, Detjen A. Tuberkulose und nicht tuberkulöse mykobakterielle Krankheiten. In: Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI), Hrsg. Infektionen bei Kindern und Jugendlichen. Stuttgart: Thieme; 2009
• 155 Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose. http://www.dzk-tuberkulose.de/
• 156 Jordan TS, Cullen D, Davies PDO. A centralised electronic Multidrug-Resistant Tuberculosis Advisory Service: the first 2 years. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 950-954
• 157 Olaru ID, Lange C, Indra A. et al. High Rates of Treatment Success in Pulmonary Multidrug-Resistant Tuberculosis by Individually Tailored Treatment Regimens. Annals of the American Thoracic Society 2016; 13: 1271-1278
• 158 National Institute for Health and Care Excellence. Tuberculosis: Prevention, Diagnosis, Management and Service Organisation (NICE Guideline, No. 33.). London (UK): NICE; 2016
• 159 Department of Health Republic of South Africa. Management of drug-resistant tuberculosis, policy guidelines. Pretoria, Rep. of South Africa: Department of Health Republic of South Africa; 2013
• 160 American Thoracic Society, CDC, Infectious Diseases Society of America. Treatment of Tuberculosis. MMWR 2003; 52: 1-77
• 161 Caminero J. Guidelines for Clinical and Operational Management of Drug-Resistant Tuberculosis. Paris, France: International Union Against Tuberculosis and Lung Disease; 2013
• 162 Dheda K, Barry 3rd CE, Maartens G. Tuberculosis. Lancet 2015; 387: 1211-1226
• 163 Banerjee R, Allen J, Westenhouse J. et al. Extensively drug-resistant tuberculosis in california, 1993–2006. Clin Infect Dis 2008; 47: 450-457
• 164 European Centre for Disease Prevention and Control. WHO Regional Office for Europe. Tuberculosis surveillance and monitoring in Europe 2016. Stockholm: European Centre for Disease Prevention and Control; 2016
• 165 Gunther G, Lange C, Alexandru S. et al. Treatment Outcomes in Multidrug-Resistant Tuberculosis. N Engl J Med 2016; 375: 1103-1105
• 166 van Leth F, Kalisvaart NA, Erkens CGM. et al. Projection of the number of patients with tuberculosis in the Netherlands in 2030. Eur J Public Health 2009; 19: 424-427
• 167 Gunther G, van Leth F, Alexandru S. et al. Multidrug-resistant tuberculosis in Europe, 2010-2011. Emerg Infect Dis 2015; 21: 409-416
• 168 Domínguez J, Boettger EC, Cirillo D. et al. Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus statement. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2016; 20: 24-42
• 169 Walker TM, Kohl TA, Omar SV. et al. Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study. Lancet Infect Dis 2015; 3099: 1-10
• 170 Lange C, Duarte R, Frechet-Jachym M. et al. Limited Benefit of the New Shorter Multidrug-Resistant Tuberculosis Regimen in Europe. Am J Respir Crit Care Med 2016; 194: 1029-1031
• 171 Diacon AH, Pym A, Grobusch MP. et al. Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. N Engl J Med 2014; 371: 723-732
• 172 Pym AS, Diacon AH, Tang S-J. et al. Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. Eur Respir J 2016; 47: 564-574
• 173 Payen MC, De Wit S, Martin C. et al. Clinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis [Case study]. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 558-560
• 174 Gler MT, Skripconoka V, Sanchez-Garavito E. et al. Delamanid for Multidrug-Resistant Pulmonary Tuberculosis. N Engl J Med 2012; 366: 2151-2160
• 175 Tang S, Yao L, Hao X. et al. Clofazimine for the Treatment of Multidrug-Resistant Tuberculosis: Prospective, Multicenter, Randomized Controlled Study in China. Clin Infect Dis 2015; 60: 1361-1367
• 176 Olaru ID, von Groote-Bidlingmaier F, Heyckendorf J. et al. Novel drugs against tuberculosis: a clinicianʼs perspective. Eur Respir J 2015; 45: 1119-1131
• 177 Günther G, van Leth F, Altet N. et al. Beyond multidrug-resistant tuberculosis in Europe: a TBNET study. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2015; 19: 1524-1527
• 178 Yablonski P, Cordos I, Sokolovich E. et al. Surgical treatment of pulmonary tuberculosis. Eur Respir Monogr 2013; 61: 20-36
• 179 Fox GJ, Mitnick CD, Benedetti A. et al. Surgery as an Adjunctive Treatment for Multidrug-Resistant Tuberculosis: An Individual Patient Data Metaanalysis. Clin Infect Dis 2016; 62: 887-895
• 180 Brunelli A, Charloux A, Bolliger CT. et al. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J 2009; 34: 17-41
• 181 Halezeroglu S, Okur E. Thoracic surgery for haemoptysis in the context of tuberculosis: what is the best management approach?. J Thorac Dis 2014; 6: 182-185
• 182 Farid S, Mohamed S, Devbhandari M. et al. Results of surgery for chronic pulmonary Aspergillosis, optimal antifungal therapy and proposed high risk factors for recurrence – a National Centreʼs experience. J Cardiothorac Surg 2013; 8: 180
• 183 Sagan D, Gozdziuk K. Surgery for pulmonary aspergilloma in immunocompetent patients: no benefit from adjuvant antifungal pharmacotherapy. Ann Thorac Surg 2010; 89: 1603-1610
• 184 Si Z-L, Kang L-L, Shen X-B. et al. Adjuvant Efficacy of Nutrition Support During Pulmonary Tuberculosis Treating Course: Systematic Review and Meta-analysis. Chin Med J 2015; 128: 3219-3230
• 185 Kaufmann SHE, Lange C, Rao M. et al. Progress in tuberculosis vaccine development and host-directed therapies – a state of the art review. Lancet Respir Med 2014; 2: 301-320
• 186 Linseisen J, Bechthold A, Bischoff-Ferrari HA. et al. Vitamin D und Prävention ausgewählter chronischer Krankheiten. Bonn: Deutsche Gesellschaft für Ernährung e. V. (DGE); 2011
• 187 Parida SK, Axelsson-Robertson R, Rao MV. et al. Totally drug-resistant tuberculosis and adjunct therapies. J Intern Med 2015; 277: 388-405
• 188 de Grass D, Manie S, Amosun SL. Effectiveness of a home-based pulmonary rehabilitation programme in pulmonary function and health related quality of life for patients with pulmonary tuberculosis: a pilot study. Afr Health Sci 2014; 14: 866-872
• 189 Peltzer K, Naidoo P, Matseke G. et al. Prevalence of post-traumatic stress symptoms and associated factors in tuberculosis (TB), TB retreatment and/or TB–HIV co-infected primary public health-care patients in three districts in South Africa. Psychol health med 2013; 18: 387-397
• 190 Bloss E, Kukša L, Holtz TH. et al. Adverse events related to multidrug-resistant tuberculosis treatment, Latvia, 2000–2004. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2010; 14: 275-281
• 191 Yew WW, Leung CC. Antituberculosis drugs and hepatotoxicity. Respirology 2006; 11: 699-707
• 192 Lehloenya RJ, Dheda K. Cutaneous adverse drug reactions to anti-tuberculosis drugs: state of the art and into the future. Expert Rev Anti Infect Ther 2012; 10: 475-486
• 193 Kass JS, Shandera WX. Nervous system effects of antituberculosis therapy. CNS drugs 2010; 24: 655-667
• 194 de Jager P, van Altena R. Hearing loss and nephrotoxicity in long-term aminoglycoside treatment in patients with tuberculosis. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2002; 6: 622-627
• 195 Xu HB, Jiang RH, Li L. et al. Linezolid in the treatment of MDR-TB: a retrospective clinical study. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 358-363
• 196 Lange C, Abubakar I, Alffenaar JW. et al. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement. Eur Respir J 2014; 44: 23-63
• 197 Douros A, Grabowski K, Stahlmann R. Safety issues and drug-drug interactions with commonly used quinolones. Expert opinion on drug metabolism & toxicology 2015; 11: 25-39
• 198 Palacios E, Dallman R, Munoz M. et al. Drug-resistant tuberculosis and pregnancy: treatment outcomes of 38 cases in Lima, Peru. Clin Infect Dis 2009; 48: 1413-1419
• 199 Gupta A, Mathad JS, Abdel-Rahman SM. et al. Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements From an International Expert Panel. Clin Infect Dis 2016; 62: 761-769
• 200 Mathad JS, Gupta A. Tuberculosis in pregnant and postpartum women: epidemiology, management, and research gaps. Clin Infect Dis 2012; 55: 1532-1549
• 201 Duszynska W, Taccone FS, Hurkacz M. et al. Therapeutic drug monitoring of amikacin in septic patients. Crit Care 2013; 17: R165
• 202 Veinstein A, Venisse N, Badin J. et al. Gentamicin in Hemodialyzed Critical Care Patients: Early Dialysis after Administration of a High Dose Should Be Considered. Antimicrob Agents Chemother 2013; 57: 977-982
• 203 Migliori GB, Eker B, Richardson MD. et al. A retrospectve TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis. Eur Respir J 2009; 34: 387-393
• 204 PAS-Fatol N Pulver zur Herstellung einer Infusionslösung (Fachinformation). Zulassungsnummer 6192614.00.00. Stand 05/2015 Greifswald-Insel Riems: Riemser Pharma GmbH.
• 205 Terizidon 250 mg Hartkapseln (Fachinformation). Zulassungsnummer: 82515.00.00. Stand 07/2016 Greifswald-Insel Riems: Riemser Pharma GmbH.
• 206 Galietti F, Giorgis GE, Oliaro A. et al. [Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]. Minerva medica 1990; 82: 477-481
• 207 Lamprene® (clofazimine) soft gelantine capsules (prescribing information). In: Novartis Pharmaceuticals Corporation. Stand 07/2002
• 208 Lewis JM, Sloan DJ. The role of delamanid in the treatment of drug-resistant tuberculosis. Ther Clin Risk Manag 2015; 11: 779
• 209 Fox GJ, Menzies D. A Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant Tuberculosis. Infec Dis and Ther 2013; 2: 123-144
• 210 Ahuja SD, Ashkin D, Avendano M. et al. Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients. PLoS Medicine 2012; 9: e1001300-e1001300
• 211 Van Deun A, Aung KJM, Halim MA. et al. Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis. Am J Respir Crit Care Med 2010; 182: 684-692
• 212 Kuaban C, Noeske J, Rieder HL. et al. High effectiveness of a 12-month regimen for MDR-TB patients in Cameroon. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2015; 19: 517-524
• 213 Piubello A, Harouna SH, Souleymane MB. et al. High cure rate with standardised short-course multidrug-resistant tuberculosis treatment in Niger: no relapses. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2014; 18: 1188-1194
• 214 Heyckendorf J, Olaru ID, Ruhwald M. et al. Getting personal perspectives on individualized treatment duration in multidrug-resistant and extensively drug-resistant tuberculosis. Am J Respir Crit Care Med 2014; 190: 374-383
• 215 World Health Organization. Definitions and reporting framework for tuberculosis - 2013 revision. Geneva: WHO; 2013
• 216 Connor S, Foley K, Harding R. et al. Declaration on palliative care and MDR/XDR-TB. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 712-713
• 217 World Health Organization Regional Office for Europe. Roadmap to Prevent and Combat Drug-resistant Tuberculosis. Kopenhagen: World Health Organization, Regional Office for Europe; 2011
• 218 Harding R, Foley KM, Connor SR. et al. Palliative and end-of-life care in the global response to multidrug-resistant tuberculosis. Lancet Infect Dis 12: 643-646
• 219 Djoba Siawaya JF, Ruhwald M, Eugen-Olsen J. et al. Correlates for disease progression and prognosis during concurrent HIV/TB infection. Int J Infect Dis 2007; 11: 289-299
• 220 World Health Organization. Tuberculosis prevalence surveys: a handbook. Geneva: World Health Organization; 2011
• 221 World Health Organization. Global Tuberculosis Report 2015. Geneva: World Health Organization; 2015 20. Aufl.
• 222 Fiebig L, Kollan C, Hauer B. et al. HIV-prevalence in tuberculosis patients in Germany, 2002-2009: an estimation based on HIV and tuberculosis surveillance data. PLoS One 2012; 7: e49111
• 223 Burman WJ, Jones BE. Clinical and radiographic features of HIV-related tuberculosis. Semin Respir Infect 2003; 18: 263-271
• 224 Mase SR, Ramsay A, Ng V. et al. Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2007; 11: 485-495
• 225 Smith RL, Yew K, Berkowitz KA. et al. Factors affecting the yield of acid-fast sputum smears in patients with HIV and tuberculosis. Chest 1994; 106: 684-686
• 226 Rangaka MX, Wilkinson KA, Glynn JR. et al. Predictive value of interferon-gamma release assays for incident active tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12: 45-55
• 227 Uthman OA, Okwundu C, Gbenga K. et al. Optimal Timing of Antiretroviral Therapy Initiation for HIV-Infected Adults With Newly Diagnosed Pulmonary Tuberculosis: A Systematic Review and Meta-analysis. Ann Intern Med 2015; 163: 32-39
• 228 Abay SM, Deribe K, Reda AA. et al. The Effect of Early Initiation of Antiretroviral Therapy in TB/HIV-Coinfected Patients: A Systematic Review and Meta-Analysis. Journal of the International Association of Providers of AIDS Care 2015; 14: 560-570
• 229 Havlir DV, Kendall MA, Ive P. et al. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N Engl J Med 2011; 365: 1482-1491
• 230 Abdool Karim SS, Naidoo K, Grobler A. et al. Timing of initiation of antiretroviral drugs during tuberculosis therapy. N Engl J Med 2010; 362: 697-706
• 231 Blanc FX, Sok T, Laureillard D. et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N Engl J Med 2011; 365: 1471-1481
• 232 Mfinanga SG, Kirenga BJ, Chanda DM. et al. Early versus delayed initiation of highly active antiretroviral therapy for HIV-positive adults with newly diagnosed pulmonary tuberculosis (TB-HAART): a prospective, international, randomised, placebo-controlled trial. Lancet Infect Dis 2014; 14: 563-571
• 233 Torok ME, Yen NT, Chau TT. et al. Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)-associated tuberculous meningitis. Clin Infect Dis 2011; 52: 1374-1383
• 234 Dheda K, Shean K, Zumla A. et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet 2010; 375: 1798-1807
• 235 Pietersen E, Ignatius E, Streicher EM. et al. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. Lancet 2014; 383: 1230-1239
• 236 Breen Ra M, Smith CJ, Bettinson H. et al. Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection. Thorax 2004; 59: 704-707
• 237 Meintjes G, Lawn SD, Scano F. et al. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 2008; 8: 516-523
• 238 Müller M, Wandel S, Colebunders R. et al. Incidence and Lethality of Immune Reconstitution Disease in HIV-Infected Patients Starting Antiretroviral Therapy: Systematic Review and Meta-Analysis. Lancet Infect Dis 2010; 10: 251-261
• 239 Marais S, Meintjes G, Pepper DJ. et al. Frequency, Severity, and Prediction of Tuberculous Meningitis Immune Reconstitution Inflammatory Syndrome. Clin Infect Dis 2013; 56: 450-460
• 240 Pepper DJ, Marais S, Maartens G. et al. Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series. Clin Infect Dis 2009; 48: e96-107
• 241 Lai RP, Meintjes G, Wilkinson RJ. HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome. Semin Immunopathol 2016; 38: 185-198
• 242 Meintjes G, Wilkinson RJ, Morroni C. et al. Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS (London, England) 2010; 24: 2381-2390
• 243 Meintjes G, Skolimowska KH, Wilkinson KA. et al. Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med 2012; 186: 369-377
• 244 Volkow PF, Cornejo P, Zinser JW. et al. Life-threatening exacerbation of Kaposi's sarcoma after prednisone treatment for immune reconstitution inflammatory syndrome. AIDS (London, England) 2008; 22: 663-665
• 245 Meintjes G, Scriven J, Marais S. Management of the immune reconstitution inflammatory syndrome. Current HIV/AIDS reports 2012; 9: 238-250
• 246 Meintjes G, Rangaka MX, Maartens G. et al. Novel relationship between tuberculosis immune reconstitution inflammatory syndrome and antitubercular drug resistance. Clin Infect Dis 2009; 48: 667-676
• 247 Thwaites GE, Bang ND, Dung NH. et al. Dexamethasone for the Treatment of Tuberculous Meningitis in Adolescents and Adults. N Engl J Med 2004; 351: 1741-1751
• 248 Lipman M, Breen R. Immune reconstitution inflammatory syndrome in HIV. Curr Opin in Infect Dis 2006; 19: 20-25
• 249 Centers for Disease Control and Prevention. Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis. Im Internet: http://www.cdc.gov/tb/TB_HIV_Drugs/default.htm
• 250 Hoppe LE, Kettle R, Eisenhut M. et al. Tuberculosis – diagnosis, management, prevention, and control: summary of updated NICE guidance. BMJ 2016; 352: h6747
• 251 Baciewicz AM, Chrisman CR, Finch CK. et al. Update on rifampin, rifabutin, and rifapentine drug interactions. Curr Med Res Opin 2013; 29: 1-12
• 252 Niemi M, Backman JT, Fromm MF. et al. Pharmacokinetic interactions with rifampicin: clinical relevance. Clin Pharmacokinet 2003; 42: 819-850
• 253 Taburet AM, Sauvageon H, Grinsztejn B. et al. Pharmacokinetics of Raltegravir in HIV-Infected Patients on Rifampicin-Based Antitubercular Therapy. Clin Infect Dis 2015; 61: 1328-1335
• 254 Wenning LA, Hanley WD, Brainard DM. et al. Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir. Antimicrob Agents Chemother 2009; 53: 2852-2856
• 255 Dooley KE, Sayre P, Borland J. et al. Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: results of a phase 1 study among healthy subjects. J Acquir Immune Defic Syndr 2013; 62: 21-27
• 256 Grinsztejn B, De Castro N, Arnold V. et al. Raltegravir for the treatment of patients co-infected with HIV and tuberculosis (ANRS 12 180 Reflate TB): a multicentre, phase 2, non-comparative, open-label, randomised trial. Lancet Infect Dis 2014; 14: 459-467
• 257 Luetkemeyer AF, Rosenkranz SL, Lu D. et al. Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study. Clin Infect Dis 2015; 60: 1860-1863
• 258 Luetkemeyer AF, Rosenkranz SL, Lu D. et al. Relationship between weight, efavirenz exposure, and virologic suppression in HIV-infected patients on rifampin-based tuberculosis treatment in the AIDS Clinical Trials Group A5221 STRIDE Study. Clin Infect Dis 2013; 57: 586-593
• 259 Dooley KE, Denti P, Martinson N. et al. Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection. J Infect Dis 2015; 211: 197-205
• 260 Jiang HY, Zhang MN, Chen HJ. et al. Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a systematic review and meta-analysis. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2014; 25: 130-135
• 261 van Oosterhout JJ, Kumwenda JJ, Beadsworth M. et al. Nevirapine-based antiretroviral therapy started early in the course of tuberculosis treatment in adult Malawians. Antivir Ther 2007; 12: 515-521
• 262 Boulle A, Van Cutsem G, Cohen K. et al. Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy. JAMA 2008; 300: 530-539
• 263 Avihingsanon A, Manosuthi W, Kantipong P. et al. Pharmacokinetics and 48-week efficacy of nevirapine: 400 mg versus 600 mg per day in HIV-tuberculosis coinfection receiving rifampicin. Antivir Ther 2008; 13: 529-536
• 264 Loeliger A, Suthar AB, Ripin D. et al. Protease inhibitor-containing antiretroviral treatment and tuberculosis: can rifabutin fill the breach?. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 6-15
• 265 Masur H, Brooks JT, Benson CA. et al. Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2014; 58: 1308-1311
• 266 Jo KW, Yoo JW, Hong Y. et al. Risk factors for 1-year relapse of pulmonary tuberculosis treated with a 6-month daily regimen. Respiratory medicine 2014; 108: 654-659
• 267 Ahmad Khan F, Minion J, Al-Motairi A. et al. An updated systematic review and meta-analysis on the treatment of active tuberculosis in patients with HIV infection. Clin Infect Dis 2012; 55: 1154-1163
• 268 Karo B, Krause G, Hollo V. et al. Impact of HIV infection on treatment outcome of tuberculosis in Europe. Aids 2016; 30: 1089-1098
• 269 Srivastava S, Pasipanodya JG, Meek C. et al. Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability. J Infect Dis 2011; 204: 1951-1959
• 270 Pasipanodya JG, Srivastava S, Gumbo T. Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy. Clin Infect Dis 2012; 55: 169-177
• 271 Pasipanodya JG, McIlleron H, Burger A. et al. Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes. J Infect Dis 2013; 208: 1464-1473
• 272 Smythe W, Khandelwal A, Merle C. et al. A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients. Antimicrob Agents Chemother 2012; 56: 2091-2098
• 273 Sotgiu G, Alffenaar JW, Centis R. et al. Therapeutic drug monitoring: how to improve drug dosage and patient safety in tuberculosis treatment. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2015; 32: 101-104
• 274 Aarnoutse RE, Sturkenboom MGG, Robijns K. et al. An interlaboratory quality control programme for the measurement of tuberculosis drugs. Eur Respir J 2015; 46: 268-271
• 275 Magis-Escurra C, Later-Nijland HMJ, Alffenaar JWC. et al. Population pharmacokinetics and limited sampling strategy for first-line tuberculosis drugs and moxifloxacin. Int J Antimicrob Agents 2014; 44: 229-234
• 276 Drew BJ, Ackerman MJ, Funk M. et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation 2010; 121: 1047-1060
• 277 Sentinel Project for Pediatric Drug-Resistant Tuberculosis. Management of Multidrug-Resistant Tuberculosis in Children: A Field Guide. Boston, USA: Sentinel Project for Pediatric Drug-Resistant Tuberculosis; 2015
• 278 Kranzer K, Elamin WF, Cox H. et al. A systematic review and meta-analysis of the efficacy and safety of N-acetylcysteine in preventing aminoglycoside-induced ototoxicity: implications for the treatment of multidrug-resistant TB. Thorax 2015; 70: 1070-1077
• 279 Hugonnet J-EBJ. Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate. Biochemistry (Mosc) 2007; 46: 11998-2004
• 280 Chambers HFMD, Yajko D, Miick C. et al. Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis?. Antimicrob Agents Chemother 1995; 39: 2620-2624
• 281 Centers for Disease Control and Prevention. Provisional CDC guidelines for the use and safety monitoring of bedaquiline fumarate (Sirturo) for the treatment of multidrug-resistant tuberculosis. MMWR Recomm Rep 2013; 62: 1-12
• 282 van Heeswijk RP, Dannemann B, Hoetelmans RM. Bedaquiline: a review of human pharmacokinetics and drug-drug interactions. J Antimicrob Chemother 2014; 69: 2310-2318
• 283 Tiberi S, Payen MC, Sotgiu G. et al. Effectiveness and safety of meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB. Eur Respir J 2016; 47: 1235-1243
• 284 De Lorenzo S, Alffenaar JW, Sotgiu G. et al. Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB. Eur Respir J 2013; 41: 1386-1392
• 285 Sotgiu G, DʼAmbrosio L, Centis R. et al. Carbapenems to Treat Multidrug and Extensively Drug-Resistant Tuberculosis: A Systematic Review. International journal of molecular sciences 2016; 17: 373
• 286 Tiberi S, Sotgiu G, D'Ambrosio L. et al. Comparison of effectiveness and safety of imipenem/clavulanate- versus meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB. Eur Respir J 2016; 47: 1758-1766
• 287 Zhang Y, Yew WW. Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2015; 19: 1276-1289
• 288 Sasahara K, Shimokawa Y, Hirao Y. et al. Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo. Drug metabolism and disposition: the biological fate of chemicals 2015; 43: 1267-1276
• 289 Russo PACM. Toxic optic neuropathy associated with ethambutol: implications for current therapy. J Am Optom Assoc 1994; 65: 332-338
• 290 CLSI. Susceptibility testing of mycobacteria, norcardiae, and other aeroboic actinomycetes: approved standard-Second Edition. CLSI document M24-A2. Wayne PA USA: Clinical and Laboratory Standards Institute; 2011
• 291 Bottger EC. The ins and outs of Mycobacterium tuberculosis drug susceptibility testing. Clin Microbiol Infect 2011; 17: 1128-1134
• 292 Peloquin CA, Namdar R, Dodge AA. et al. Pharmacokinetics of isoniazid under fasting conditions, with food, and with antacids. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 1999; 3: 703-710
• 293 Du H, Chen X, Fang Y. et al. Slow N-acetyltransferase 2 genotype contributes to anti-tuberculosis drug-induced hepatotoxicity: a meta-analysis. Mol Biol Rep 2013; 40: 3591-3596
• 294 Wang PY, Xie SY, Hao Q. et al. NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2012; 16: 589-595
• 295 Azuma J, Ohno M, Kubota R. et al. NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: a randomized controlled trial for pharmacogenetics-based therapy. Eur J Clin Pharmacol 2013; 69: 1091-1101
• 296 Bothahemley G. Drug treatment for tuberculosis during pregnancy: safety. Drug Saf 2001; 24: 553-565
• 297 Lee M, Lee J, Carroll MW. et al. Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N Engl J Med 2012; 367: 1508-1518
• 298 Sotgiu G, Centis R, D'Ambrosio L. et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur Respir J 2012; 40: 1430-1442
• 299 Zhang X, Falagas ME, Vardakas KZ. et al. Systematic review and meta-analysis of the efficacy and safety of therapy with linezolid containing regimens in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis. J Thorac Dis 2015; 7: 603-615
• 300 Koh W-JKO, Gwak H, Chung JW. et al. aily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis. J Antimicrob Chemother 2009; 64: 388-391
• 301 Diacon AH, van der Merwe L, Barnard M. et al. beta-Lactams against Tuberculosis--New Trick for an Old Dog?. N Engl J Med 2016; 375: 393-394
• 302 Brennan JPYD. Handbook of Anti-Tuberculosis Agents: Global Alliance for TB Drug Development. 2008
• 303 Yew WW. Clinically significant interactions with drugs used in the treatment of tuberculosis. Drug Saf 2002; 25: 111-133
• 304 Burman WJ, Gallicano K, Peloquin C. Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials. Clin Pharmacokinet 2001; 40: 327-341