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Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 2017; 27(04): 205-210
DOI: 10.1055/s-0043-113045
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Rheumatic Diseases and Molecular Physical Medicine – New Aspects

Rheumatische Erkrankungen und molekulare physikalische Medizin – Neue Aspekte
Uwe Lange
1   Department of Rheumatology, Osteology and Physical Medicine, Kerckhoff-Klinik, University Gießen, Bad Nauheim, Germany
,
Ulf Müller-Ladner
1   Department of Rheumatology, Osteology and Physical Medicine, Kerckhoff-Klinik, University Gießen, Bad Nauheim, Germany
,
Gabriel Dischereit
1   Department of Rheumatology, Osteology and Physical Medicine, Kerckhoff-Klinik, University Gießen, Bad Nauheim, Germany
› Author Affiliations
Further Information

Publication History

received 13 March 2017

accepted 06 June 2017

Publication Date:
04 September 2017 (online)

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Abstract

A multimodal treatment of rheumatic diseases without physical medicine is incomplete. However, the mechanisms underlying the beneficial effects of physical medicine are only partially understood. Modern molecular medicine offers new insights into pivotal mechanisms and mediators of the inflammatory process and into interactions between cells of the immune system and bone cells. Investigating the potential influences of different methods of physical medicine on the central regulatory processes of inflammatory rheumatic diseases is of great interest, highly fascinating and opens up new avenues of research for the future. This article focuses on the novel results of molecular physical medicine in rheumatic diseases and osteoporosis.

Zusammenfassung

Eine multimodale Therapie von rheumatischen Erkrankungen ohne physikalisch-medizinische Maßnahmen ist stets inkomplett. Die Wirkungsmechanismen, die der klinischen Verbesserung durch physikalische Maßnahmen zugrunde liegen, sind bisher nur teilweise bekannt. Methoden der molekularen Medizin ermöglichen es inzwischen zentrale Botenstoffe des inflammatorischen Geschehens – die u. a. für die Wechselbeziehungen zwischen Knochen- und Immunzellen von zentraler Bedeutung sind – und deren Beeinflussung durch Applikation physikalischer Therapiemaßnahmen zu analysieren. Der Eingriff in dieses zentrale Regulationssystem bei rheumatischen Erkrankungen und Osteoporose durch Physiotherapeutika ist spannend und faszinierend zugleich und bietet zukünftig ein großes Forschungsfeld. Der vorliegende Artikel bietet einen Überblick über erste Resultate auf diesem neuen Forschungsfeld der molekularen physikalischen Medizin.

Key words

musculoskeletal diseases - physical medicine - molecular physical medicine - osteoporosis - cytokines

Schlüsselwörter

muskuloskelettale Erkrankungen - physikalische Medizin - molekulare physikalische Medizin - Osteoporose - Zytokine
 

  • References

  • 1 Braun J, van den Berg R, Baraliakos X. et al. 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 2011; 70: 896-904
    CrossrefPubMedSearch in Google Scholar
  • 2 Schneider M, Krüger K. Rheumatoid arthritis – early diagnosis and disease management. Dtsch Arztebl Int 2013; 110: 477-484
    PubMedSearch in Google Scholar
  • 3 Kiltz U, Mau W, Repschläger U. et al. 2014; German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew’s disease and early forms: 8.7 Rehabilitation. Z Rheumatol 2014; 73 (Suppl. 02) 101-103
    CrossrefPubMedSearch in Google Scholar
  • 4 Albrecht K, Huscher D, Eidner T. et al. Medical treatment of rheumatoid arthritis in 2014: Current data from the German Collaborative Arthritis Centers. Z Rheumatol 2017; 76: 50-57
    CrossrefPubMedSearch in Google Scholar
  • 5 Huscher D, Thiele K, Rudwaleit M. et al. Trends in treatment and outcomes of ankylosing spondylitis in outpatient rheumatological care in Germany between 2000 and 2012. RMD Open 2015; 1 e000033
    PubMedSearch in Google Scholar
  • 6 Weigl M, Schwarzkopf SR, Stucki G. Using the international classification of functioning, disability, and health in rheumatologic rehabilitation. Z Rheumatol 2008; 67: 565-574
    CrossrefPubMedSearch in Google Scholar
  • 7 Braun J, Zochling J, Grill E. et al. International classification of functioning, disability and health and its significance for rheumatology. Z Rheumatol 2007; 66: 603-610
    CrossrefPubMedSearch in Google Scholar
  • 8 Huscher D, Merkesdal S, Thiele K. et al. German Collaborative Arthritis Centers. Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and SLE in Germany. Ann Rheum Dis 2006; 65: 1175-1183
    CrossrefPubMedSearch in Google Scholar
  • 9 Lange U. Molecular physical medicine. Z Rheumatol 2012; 71: 381-386
    CrossrefPubMedSearch in Google Scholar
  • 10 Tarner IH, Lange U. Molecular physical medicine in rheumatology: Fake or reality?. Akt Rheumatol 2014; 39: 298-303
    Thieme ConnectPubMedSearch in Google Scholar
  • 11 Schmidt KL, Ott VR, Röcher G. et al. Heat, cold and inflammation. Z Rheumatol 1979; 38: 392-404
    PubMedSearch in Google Scholar
  • 12 Lange U, Uhlemann C, Müller-Ladner U. Serial whole-body cryotherapy in the Criostream for inflammatory rheumatic diseases. A pilot study. Med Klin 2008; 103: 383-388
    CrossrefPubMedSearch in Google Scholar
  • 13 Huang YH, Haegerstrand A, Frostegard J. Effects of invitra hyperthermias on proliferative responses and lymphocytes activity. Clin Exp Immunol 1996; 103: 61-66
    CrossrefPubMedSearch in Google Scholar
  • 14 Lange U, Müller-Ladner U, Schmidt KL. Balneotherapy in rheumatic diseases – an overview of novel and known aspects. Rheumatol Int 2006; 26: 497-499
    CrossrefPubMedSearch in Google Scholar
  • 15 Schmidt KL. Effects of whole body hyperthermia on inflammations and immune reactions: Experimental aspects. Phys Med Rehab Kuror 2004; 14: 227-235
    Thieme ConnectPubMedSearch in Google Scholar
  • 16 Lange U, Thielen G, Neeck G. et al. Effects of whole body hyperthermia on plasma cortisol, total lymphocytes and –subpopulation in patients with Ankylosing Spondylitis and healthy controls. Phys Med Rehab Kuror Med 2005; 15: 44-47
    PubMedSearch in Google Scholar
  • 17 Tarner IH, Müller-Ladner U, Uhlemann C. et al. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1beta, and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 28: 397-402
    CrossrefPubMedSearch in Google Scholar
  • 18 Lange U, Schwab F, Müller-Ladner U. et al. Effectiveness of whole-body hyperthermia by mild water-filtered infrared A radiation in psoriatic arthritis: A controlled, randomised, prospective trial. Akt Rheumatol 2014; 39: 310-316
    Thieme ConnectPubMedSearch in Google Scholar
  • 19 Lange U, Neumann S, Tarner I. et al. Effectiveness of whole-body hyperthermia by mild water-filtered infrared A radiation in Ankylosing spondylitis: A controlled, randomised, prospective trial. Akt Rheumatol 2017; 42: 122-128
    Thieme ConnectPubMedSearch in Google Scholar
  • 20 Dischereit G, Neumann N, Müller-Ladner U. et al. The impact of serial low-dose radon hyperthermia exposure on pain, disease activity and pivotal cytokines of bone metabolism in ankylosing spondylitis – a prospective study. Akt Rheumatol 2014; 39: 304-309
    Thieme ConnectPubMedSearch in Google Scholar
  • 21 Dischereit G, Fetaj J, Goronzy JE. et al. Effectiveness of serial mud baths in osteoarthritis on parameters of functional health and cytokines – a controlled, randomised, prospective trial. Akt Rheumatol 2014; 42: 129-136
    Thieme ConnectPubMedSearch in Google Scholar
  • 22 Moder A, Hufnagel C, Lind-Albrecht G. et al. Effect of combined Low-Dose Radon- and Hyperthermia Treatment (LDRnHT) of patients with ankylosing spondylitis on serum levels of cytokines and bone metabolism markers: a pilot study. Int J Low Radiation 2010; 7: 423-435
    CrossrefPubMedSearch in Google Scholar
  • 23 Lange U, Neumann N, Kürten B. et al. The impact of serial low-dose radon and hyperthermia exposure in a therapeutic adit on pivotal cytokines of bone metabolism in ankylosing spondylitis. Phys Med Rehab Kuror 2012; 22: 203-206
    Thieme ConnectPubMedSearch in Google Scholar
  • 24 Lange U, Dischereit G, Tarner I. et al. The impact of serial radon and hyperthermia exposure in a therapeutic adit on pivotal cytokines of bone metabolism in rheumatoid arthritis and osteoarthritis. Clin Rheumatol 2016; 35: 2783-2788
    CrossrefPubMedSearch in Google Scholar
  • 25 Dischereit G, Müller-Ladner U, Lange U. Effects of osteoporosis specific standardized physical therapy on functional capacity, bone mineral density and bone metabolism – a 2-year prospective and randomized study. Phys Med Rehab Kuror 2016; 26: 124-129
    Thieme ConnectPubMedSearch in Google Scholar
  • 26 Meier F, Müller-Ladner U, Lange U. Efficacy of intensive physiotherapy in combination with low-dose etanercept in active spondyloarthritis: a monocentric pilot study. J Rheumatol 2014; 41: 1897-1898
    CrossrefPubMedSearch in Google Scholar