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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(03): 237-245
DOI: 10.1055/s-0044-101613
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Update Breast Cancer 2018 (Part 1) – Primary Breast Cancer and Biomarkers

Article in several languages: English | deutsch
Florin-Andrei Taran
1   Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
,
Andreas Schneeweiss
2   National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg, Germany
3   Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
,
Michael P. Lux
4   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Wolfgang Janni
5   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Andreas D. Hartkopf
1   Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
,
Naiba Nabieva
4   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Friedrich Overkamp
6   OncoConsult Hamburg GmbH, Hamburg, Germany
,
Hans-Christian Kolberg
7   Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
,
Peyman Hadji
8   Department of Bone Oncology, Nordwest Hospital, Frankfurt, Germany
,
Hans Tesch
9   Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany
,
Achim Wöckel
10   Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
,
Johannes Ettl
11   Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
,
Diana Lüftner
12   Charité University Hospital, Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany
,
Markus Wallwiener
3   Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
,
Volkmar Müller
13   Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
,
Matthias W. Beckmann
4   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Erik Belleville
14   ClinSol GmbH & Co KG, Würzburg, Germany
,
Diethelm Wallwiener
1   Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
,
Sara Y. Brucker
1   Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany
,
Peter A. Fasching
4   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Tanja N. Fehm
15   Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
,
Florian Schütz
3   Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
› Author Affiliations
Further Information

Publication History

received 19 January 2018
revised 24 January 2018

accepted 24 January 2018

Publication Date:
21 March 2018 (online)

Also available at
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Abstract

This summary provides an overview of how new therapies or new aspects of established therapies relate to the latest findings. Neoadjuvant therapy, local therapy, new aspects of systemic therapy, and prognostic and predictive factors are presented. In the neoadjuvant setting, the association between pathological complete response (pCR) and prognosis is still of interest as is the identification of new molecular predictors for new therapies such as CDK4/6 inhibitors. As regards surgical treatment, the target is still to reduce the aggressiveness of surgery. To achieve this, a better understanding particularly of ductal carcinoma in situ is required. With regard to systemic therapy, more data on the best combinations and therapy sequences for existing therapies is available. Finally, the use of prognostic and predictive factors may help to avoid overtreatment and ensure that patients only receive therapies which have been shown to be effective for their specific condition and have fewer side effects.

Key words

breast cancer - treatment/therapy - local recurrence - trials - prognostic factors - predictive factors
 

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