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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(04): s00441786037
DOI: 10.1055/s-0044-1786037
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Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 2

Princípios da estimulação cerebral profunda na doença de Parkinson na prática clínica: parte 2
Mariana Moscovich 
1   Christian-Albrechts University, Department of Neurology, Kiel, Germany.
,
Camila Henriques de Aquino 
2   University of Calgary, Cumming School of Medicine, Department of Clinical Neurosciences, Calgary, AB, Canada.
3   University of Calgary, Hotchkiss Brain Institute, Calgary, AB, Canada.
4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
,
Murilo Martinez Marinho 
4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
,
Lorena Broseghini Barcelos 
4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
,
André C. Felício 
5   Hospital Israelita Albert Einstein, São Paulo SP, Brazil.
,
Matthew Halverson 
6   University of Utah, Department of Neurology, Salt Lake City, Utah, United States.
,
Clement Hamani 
7   University of Toronto, Sunnybrook Hospital, Toronto, ON, Canada.
,
Henrique Ballalai Ferraz 
4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
,
Renato Puppi Munhoz 
8   University of Toronto, Toronto Western Hospital, Toronto, ON, Canada.
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Abstract

The field of neuromodulation has evolved significantly over the past decade. Developments include novel indications and innovations of hardware, software, and stimulation techniques leading to an expansion in scope and role of these techniques as powerful therapeutic interventions. In this review, which is the second part of an effort to document and integrate the basic fundamentals and recent successful developments in the field, we will focus on classic paradigms for electrode placement as well as new exploratory targets, mechanisms of neuromodulation using this technique and new developments, including focused ultrasound driven ablative procedures.

Resumo

O campo da neuromodulação evoluiu significativamente na última década. Esse progresso inclui novas indicações e inovações de hardware, software e técnicas de estimulação, levando a uma expansão das áreas clínicas cobertas e no papel dessas técnicas como intervenções terapêuticas eficazes. Nesta revisão, que é a segunda parte de um esforço para documentar e integrar os fundamentos básicos e os desenvolvimentos recentes e bem-sucedidos no campo, vamos nos concentrar em paradigmas clássicos para colocação de eletrodos, bem como em novos alvos exploratórios, mecanismos de neuromodulação usados por esta técnica e novos desenvolvimentos, incluindo procedimentos ablativos orientados por ultrassom focalizado.

Keywords

Deep Brain Stimulation - Parkinson Disease - Neurosurgery

Palavras-chave

Estimulação Encefálica Profunda - Doença de Parkinson - Neurocirurgia

Authors' Contributions

MM, CHA conceptualization, acquisition of data, drafting, review and editing the manuscript; MMM, LBB, ACF: drafting, review and editing the manuscript; MH: interpretation of data and manuscript revision; CH, HBF: drafting, review and editing the manuscript; RPM: conceptualization, acquisition of data, drafting, review and editing the manuscript. MM, CHA, RPM: These authors equally contributed to this work.




Publication History

Received: 05 August 2023

Accepted: 30 October 2023

Article published online:
23 April 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Mariana Moscovich, Camila Henriques de Aquino, Murilo Martinez Marinho, Lorena Broseghini Barcelos, André C. Felício, Matthew Halverson, Clement Hamani, Henrique Ballalai Ferraz, Renato Puppi Munhoz. Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 2. Arq Neuropsiquiatr 2024; 82: s00441786037.
DOI: 10.1055/s-0044-1786037
 

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