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Semin Reprod Med 2024; 42(03): 197-208
DOI: 10.1055/s-0044-1790225
Review Article

Impact of Antiphospholipid Syndrome on Reproductive Outcomes: Current Insights and Management Approaches

Authors

  • Lauren He

    1   Division of Rheumatology, University of Michigan, Ann Arbor, Michigan

  • Catherine Sims 

    1   Division of Rheumatology, University of Michigan, Ann Arbor, Michigan
    2   Division of Rheumatology, Duke University, Durham, North Carolina
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Abstract

Antiphospholipid syndrome (APS) is a disease characterized by the presence of antiphospholipid (aPL) antibodies, thrombosis, and obstetric complications. While patients with APS can have successful pregnancies, many important considerations exist. APS can also cooccur with other systemic autoimmune diseases which can affect pregnancy, particularly systemic lupus erythematosus. This article reviews specific considerations for pregnancy and reproductive health in patients with APS. Similar to other autoimmune diseases, stable or quiescent disease and planning with a rheumatologist and obstetrician prior to conception are vital components of a successful pregnancy. Pregnancy management for patients with aPL antibodies or diagnosis of APS with aspirin and/or anticoagulation depending on disease profile is discussed, as well as the effects of physiologic changes during pregnancy in maternal and fetal outcomes for this population. Given the reproductive span lasts beyond conception through delivery, we include discussions on safe contraception options, the use of assistive reproductive technology, pregnancy termination, menopause, and male fertility. While APS is a relatively rare condition, the effects this disease can have on maternal and fetal outcomes even with available therapies demonstrates the need for more high-quality, evidence-based research.

Keywords

antiphospholipid syndrome - pregnancy - reproduction


Publication History

Article published online:
24 October 2024

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