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Synthesis 1986; 1986(12): 1041-1044
DOI: 10.1055/s-1986-31867
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Improved One-Step Procedure for the Preparation of 1-Substituted and 1,3-Disubstituted Uracils and 2-Thiouracils

Ib Winckelmann* , Erik H. Larsen
  • *Research Dept., A/S Cheminova, P.O. Box 9, DK-7620 Lemvig, Denmark
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Publication Date:
12 September 2002 (online)

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A convenient one-pot procedure for the synthesis of 1-substituted and 1,3- disubstituted uracils and 2-thiouracils consists of acylation of ureas, or thioureas with methyl 3,3-dimethoxypropanoate in the presence of a strong base, and acidic work-up. The yields range from 36 to 99%. In all cases, only one regioisomer is isolated.