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Synthesis 1988; 1988(6): 444-448
DOI: 10.1055/s-1988-27602
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Synthesis of N-(Diisopropyloxyphosphoryl)amino Acids and Peptides

Gai-Jiao Ji* , Chu-Biao Xue, Jia-Ning Zeng, Li-Pou Li, Wen-Gang Chai, Yu-Fen Zhao
  • *Institute of Chemistry, Academia Sinica, Beijing, People's Republic of China
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Publication History

Publication Date:
20 August 2002 (online)

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N-(Diisopropyloxyphosphoryl)amino acids (N-Dipp-amino acids) are prepared from diisopropyl phosphite and amino acids in mixed aqueous media in one step. They can be activated by dicyclohexylcarbodiimide or other activating agents for the synthesis of N-(diisopropyloxyphosphoryl)dipeptides.