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Synthesis 1989; 1989(2): 71-82
DOI: 10.1055/s-1989-27158
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The Hetero-Cope Rearrangement in Organic Synthesis

Siegfried Blechert*
  • *Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str.1, D-5300 Bonn 1, Federal Republic of Germany
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Publication History

Publication Date:
17 September 2002 (online)

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1. Introduction 2. Claisen Rearrangements 2.1. Methods of Preparation for Claisen Systems 2.2. Stereoselections 2.2.1. Cyclic Substrates 2.2.2. Acyclic Substrates 2.3. Rearrangements Accelerated by Charge 3. Aza-Cope Rearrangements 3.1. Amino-Claisen Rearrangements 3.2. 2-Aza-Cope Rearrangements 3.3. 1-Aza-Cope Rearrangements 4. 1-Aza-1′-Oxa-Cope Rearrangements 5. Miscellaneous Hetero-Cope Rearrangements This review presents a number of different variants of hetero-Cope rearrangements that have recently played an important role in organic syntheses. Modern developments concerning stereoselective and stereospecific syntheses are presented. Besides the possibilities of stereoselections, the applicability of efficient rearrangements in the course of establishing new functionalities and their use in tandem reactions is described.