Cleavage of Isoxazolines with Tricarbonyltris(acetonitrile)molybdenum and Silica Gel. Synthesis of 1-(2-Oxoalkyl)cyclopropanols from lsoxazoline-5-spirocyclopropanes

Antonio Guarna; Antonio Guidi; Andrea Goti; Alberto Brandi; Francesco De Sarlo

doi:10.1055/s-1989-27185

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Synthesis 1989; 1989(3): 175-178
DOI: 10.1055/s-1989-27185

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Cleavage of Isoxazolines with Tricarbonyltris(acetonitrile)molybdenum and Silica Gel. Synthesis of 1-(2-Oxoalkyl)cyclopropanols from lsoxazoline-5-spirocyclopropanes

Antonio Guarna^* , Antonio Guidi, Andrea Goti, Alberto Brandi, Francesco De Sarlo

^*Dipartimento di Chimica organica "Ugo Schiff", Università di Firenze, Via Gino Capponi 9, I-50121 Firenze, Italy

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Publication Date:
17 September 2002 (online)

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An efficient synthesis of 1-(2-oxoalkyl)cyclopropanols [or (1-hydroxycyclopropyl)methyl ketones] from isoxazoline-5-spirocyclopropanes by selective N-O cleavage effected by Mo(CO)₃(MeCN)₃ and silica gel is described.