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Synlett 1990; 1990(3): 151-152
DOI: 10.1055/s-1990-21016
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Cyclization of ω-Halo-N-methoxy-N-methylalkanamides Initiated by Lithium-Halogen Exchange

Michel Souchet* , Robin D. Clark
  • *Syntex Research, Institute of Organic Chemistry, 3401 Hillview Ave., Palo Alto, California 94304, USA
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Publication Date:
08 March 2002 (online)

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Four- to seven-membered ring cyclic ketones are readily available by intramolecular cyclization of ω-halo-N-methoxy-N-methylalkanamides in the presence of tert-butyllithium.