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Synlett 1991; 1991(2): 63-72
DOI: 10.1055/s-1991-20631
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Radical Reactions and Retrosynthetic Planning

Dennis P. Curran*
  • *Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA
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Publication Date:
07 March 2002 (online)

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A formal thought process and associated symbols are introduced for incorporating radical reactions into a standard retrosynthetic analysis. Examples from the recent literature that combine radical reactions either with other radical reactions or with ionic reactions illustrate how retrosynthetic planning can generate ideas for new synthetic strategies, methods, or reagents. 1. Introduction 2. New Symbols to Notate Radical Reactions in Retrosynthesis 3. Tandem Radical Cyclizations (New Notations/Old Reactions) 4. A Break from Tandem Reactions (New Notations/New Reactions) 5. Tandem Radical Cyclizations (Old Approach/New Ideas) 6. Conclusion