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Synlett 1991; 1991(3): 204-206
DOI: 10.1055/s-1991-20681
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A Dramatic Acceleration of the Pauson-Khand Reaction by Trimethylamine N-Oxide1,2

Nakcheol Jeong* , Young Keun Chung, Bun Yeoul Lee, Sang Hee Lee, Sung-Eun Yoo
  • *Korea Research Institute of Chemical Technology, Daedeogdanji, P.O. Box 9, Daejeon, South Korea
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Publication Date:
07 March 2002 (online)

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The Pauson-Khand reaction (cocyclization of alkynes with alkenes and carbon monoxide by octacarbonyldicobalt leading to cyclopentenones) was greatly accelerated by trimethylamine N-oxide in the presence of oxygen in dichloromethane at 0 °C to room temperature. This process worked quite effectively for both intermolecular and intramolecular reactions.