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Synlett 1991; 1991(7): 483-484
DOI: 10.1055/s-1991-20769
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A Facile Synthesis of 1-Arylpyrazoles by Reacting Diethyl (Ethylthiomethyl)phosphonate Carbanion with Arylhydrazones

Himatkumar V. Patel* , Kavita A. Vyas, Sudhanshu P. Pandey, Francis Tavares, P. S. Fernandes
  • *N.S.R. Laboratory, Department of Chemistry, St. Xavier's College, Bombay 400001, India
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Publication Date:
07 March 2002 (online)

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Diethyl (ethylthiomethyl)phosphonate on treatment with butyllithium at -78 °C gives the corresponding carbanion. Treatment of this carbanion with the monoarylhydrazones of 1,2-dicarbonyl compounds 2 at -70 °C followed by heating at 60 °C gives the cyclized 3,4-disubstituted 1-aryl-1H-pyrazoles 4 in good yield.