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Synlett 1992; 1992(9): 723-724
DOI: 10.1055/s-1992-21468
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Cyclopropane Construction Relative to CC-1065

T. A. Bryson* , J. H. Koen, Jr., G. A. Roth
  • *Department of Chemistry, University of South Carolina, Columbia, South Carolina 29208, USA
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Publication Date:
08 March 2002 (online)

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Intramolecular nitrile alkylations to from E- and Z-cyclopropanes have been studied utilizing a range of techniques and leaving groups. Enhanced conditions for forming Z-cyclopropyl nitriles has been applied to a nitrile pyrrole substrate that is of interest for analogs of CC-1065.