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Synthesis 1992; 1992(5): 455-457
DOI: 10.1055/s-1992-26134
short paper
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Facile and Convenient Synthetic Methods for Bis(trifluoroacetyl)ketene N,O-, N,S- and S,S-Acetals and 2,2-Bis(trifluoroacetyl)vinylamines and Sulfides

Masaru Hojo* , Ryoichi Masuda, Etsuji Okada, Yasuyuki Mochizuki
  • *Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan
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Publication Date:
17 September 2002 (online)

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Trifluoroacetylation of (trifluoroacetyl)ketene N,O-, N,S- and S,S-acetals [4-dialkylamino-4-ethoxy(methylthio)-1,1,1-trifluoro-3-buten-2-one and 4,4-bis(methylthio)-1,1,1-trifluoro-3-buten-2-one] gives the corresponding 1,1,1-trifluoro-3-(trifluoroacetyl)-3-buten-2-ones. 4-Amino- and 4-alkyl(aryl)thio-1,1,1-trifluoro-3 -(trifluoroacetyl)-3-buten-2-ones are obtained by O-N and O-S exchange reactions of 1,1,1-trifluoro-4-isobutoxy-3-(trifluoroacetyl)-3-buten-2-one with amines and thiols, respectively.