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Synlett 1994; 1994(5): 333-334
DOI: 10.1055/s-1994-22843
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Short and Efficient Synthesis of (2S)-3-(1′,1′-Dimethylethylsulfonyl) -2-(1-naphthylmethyl)-Propionic Acid, N Terminal Building Block for Protease Inhibitors

E. Wolfgang Holla* , Bernd Napierski, Heinz-Peter Rebenstock
  • *Hoechst AG, Allgemeine Pharma-Forschung, Postfach 80 03 20, D-65926 Frankfurt/M., Germany
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Publication Date:
22 March 2002 (online)

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Title compound 2 is synthesized (100 g scale) from norephedrine-derived oxazolidinone 3 in three steps in an overall yield of 37% and 99% optical purity.