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Synlett 1994; 1994(9): 754-756
DOI: 10.1055/s-1994-22998
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A New Synthesis of (R)- and (S)-Mevalonolactone from the Enzymatic Resolution of (R,S)-2-(3-Methyl-2-butenyl)-oxiranemethanoI

Patrizia Ferraboschi* , Paride Grisenti, Silvana Casati, Enzo Santaniello
  • *Dipartimento di Chimica e Biochimica Medica, Università degli Studi di Milano - Via Saldini, 50- 20133 Milano, Italy
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Publication Date:
18 September 2002 (online)

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A new chemoenzymatic synthesis of both enantiomers of mevalonolactone 1 starting from the Pseudomonas fluorescens lipasecatalyzed resolution of racemic 2-(3-methyl-2-butenyl)-oxiranemethanol 2 is reported.