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Synthesis 1994; 1994(8): 763-764
DOI: 10.1055/s-1994-25564
short paper
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Simple and Improved Preparation of α-Aminophosphonic Acid Derivatives, Key Building Blocks of Phosphonopeptides

Hideyo Takahashi* , Masato Yoshioka, Nobuyuki Imai, Kenjiro Onimura, Susumu Kobayashi
  • *Sagami Chemical Research Center, Nishi-Ohnuma, Sagamihara 229, Japan
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Publication Date:
17 September 2002 (online)

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Strecker-type reaction of an aldehyde, ammonium acetate and diethyl phosphite in ethanol afforded the corresponding diethyl α-aminophosphonate, a key building block of the biologically interesting phosphonopeptides, in moderate to good yield.