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Synthesis 1994; 1994(9): 989-992
DOI: 10.1055/s-1994-25620
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Studies On Isoxazole Formation from Alkyl Carboxylic Esters

Yun He* , Nan-Horng Lin
  • *Neuroscience Research, Pharmaceutical Products Division, Dept 47W, Abbott Laboratories, Abbott Park, Illinois 60064, USA
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Publication History

Publication Date:
17 September 2002 (online)

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Alkylisoxazoles 1a-12a were prepared in moderate to high yields (58-83%) by condensation of 1.5 equivalents of the appropriate ketone oximes with an alkyl ester, followed by a mineral acid induced cyclization-dehydration reaction.