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Synlett 1994; 1994(12): 1003-1004
DOI: 10.1055/s-1994-34974
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Synthesis of a Modified Thymidine and Preparation of Precursors of Oligonucleotide Radicals

Bernd Giese* , Petra Imwinkelried, Mario Petretta
  • *Department of Chemistry, University of Basel, St. Johanns Ring 19, CH-4056 Basel, Switzerland
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Publication Date:
22 March 2002 (online)

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The synthesis of t-butyl thymidyl ketone 13 has been accomplished starting from the substituted thymidine 9. Ketone 13 is a useful building block for the preparation of modified oligonucleotides. Irradiation of oligonucleotide 14a led selectively to cleavage products 15a and 16a.