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Synthesis 1995; 1995(12): 1491-1492
DOI: 10.1055/s-1995-4147
short paper
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One-Pot Synthesis of 3(5)-Ethoxycarbonylpyrazoles

Marcos A.P. Martins* , Rogério Freitag, Alex F.C. Flores, Nilo Zanatta
  • *Departamento de Química, Universidade Federal de Santa Maria, 97.119-900 - Santa Maria, RS, Brazil, Fax +55(55)2261259
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Publication Date:
31 December 2000 (online)

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A one-pot synthesis of ethoxycarbonylpyrazoles 2a-e, by the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones 1a-e with hydrazine hydrochloride under mild conditions, is reported. A study using compounds 1a-e with different substituents proved that these are versatile building blocks for the synthesis of pyrazole derivatives, having a 3(5)-ethoxycarbonyl substituent, in good yields (70-91%).

Ethoxycarbonylpyrazoles are prepared from β-alkoxyvinyl trichloromethyl ketones and hydrazine hydrochloride