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Synlett 1995; 1995(2): 171-172
DOI: 10.1055/s-1995-4886
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Preparation of 2-Thiazolines from (1,2)-Thioamido-Alcohols; DAST as a Useful Reagent

Pierre Lafargue, Pierre Guenot, Jean-Paul Lellouche*
  • *CEA, CE-Saclay, Département de Biologie Cellulaire et Moléculaire, Service des Molécules Marquées, Bât 547, F-91191 Gif-sur-Yvette Cedex, France
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Publication History

Publication Date:
31 December 2000 (online)

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Diethylamidosulfur trifluoride (DAST) is shown to be a valuable reagent for the ready access to 2-thiazolines 4a-f starting from the corresponding (1,2)-thioamido-alcohols 3a-f. This mild intramolecular cyclization is fast (< 1 h) and occurs at a temperature as low as -78 °C.

2-Thiazolines - DAST