Download PDF
Synlett 1995; 1995(11): 1115-1116
DOI: 10.1055/s-1995-5220
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Aryl- and Heteroaryl-Alkyne Coupling Reactions Catalyzed by Palladium on Carbon and CuI in an Aqueous Medium

Leo Bleicher, Nicholas D. P. Cosford*
  • *SIBIA, 505 Coast Boulevard South, Suite 300, La Jolla, CA 92037, Internet Cosford@SC2.salk.edu
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A protocol for the efficient coupling of alkynes with aryl and heteroaryl substrates with a Pd/C-CuI-PPh3 catalyst system in aqueous media has been developed. These conditions are tolerant of a variety of unprotected functional groups. Reactions which demonstrate the generality and scope of this methodology are reported.

alkynylation - palladium - cross-coupling - aqueous medium - multi-kilo scale