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Synthesis 1996; 1996(1): 37-38
DOI: 10.1055/s-1996-4153
short paper
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A Simple and Convenient Synthesis of N-Formyl Amino Acid Esters Under Mild Conditions

W. Duczek, J. Deutsch, S. Vieth, H.-J. Niclas*
  • *Institut für Angewandte Chemie, Berlin-Adlershof, Rudower Chaussee 5, D-12484 Berlin, Germany
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Publication Date:
31 December 2000 (online)

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A variety of amino acid ester hydrochlorides react with cyanomethyl formate at room temperature to give the N-formyl amino acid esters in good yields and without racemization.

cyanomethyl formate - N-formylation - N-formyl amino acid esters