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Synthesis 1996; 1996(5): 600-602
DOI: 10.1055/s-1996-4267
short paper
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Oxidative Decarboxylation of α-Amino and α-Hydroxy Acids Using Copper(II) Bromide-Lithium tert-Butoxide

Takeshi Takeda* , Satoshi Yamauchi, Tooru Fujiwara
  • *Department of Applied Chemistry, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184, Japan, Fax +81(423)887034; E-mail takeda-t@cc.tuat.ac.jp
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Publication Date:
31 December 2000 (online)

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α-Monoalkyl α-amino acids were oxidized to the corresponding alkanenitriles in good yields by treatment with copper(II) bromide-lithium tert-butoxide. The oxidation of α,α-disubstituted α-amino and α-hydroxy acids also gave the corresponding ketones.

oxidation - decarboxylation - α-amino acid - α-hydroxy acid - tert-butoxycopper(II) bromide