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Synthesis 1996; 1996(8): 927-929
DOI: 10.1055/s-1996-4322
short paper
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Synthesis of Imidazo[1,2-a]pyridines from Pyridines and p-Bromophenacyl Bromide O-Methyloxime

V. A. Artyomov, A. M. Shestopalov, V. P. Litvinov*
  • *N.D. Zelinsky Institute of Organic Chemistry, 117913, Moscow, Russia, Fax +7(095)1355328; E-mail LVP$251@SUEARN2.bitnet
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Publication Date:
31 December 2000 (online)

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p-Bromophenacyl bromide O-methyloxime reacts with pyridines in acetone to form the corresponding pyridinium salts which, when heated in methanol in the presence of Et3N, undergo cyclization followed by elimination of MeOH to give imidazo[1,2-a]pyridines.

imidazo[1,2-a]pyridines - pyridinium salts - regioselective cyclization - phenacyl bromide oxime