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Synlett 1996; 1996(3): 245-246
DOI: 10.1055/s-1996-5386
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Synthesis of 2-Oxazolines from Carboxylic Acids and α,α,α-Tris(hydroxymethyl)methylamine under Microwaves in Solvent-Free Conditions

A. L. Marrero-Terrero* , A. Loupy
  • *Department of Organic Chemistry, Division of Chemistry, National Center for Scientific Research (CNIC). P.O. Box 6880. Havana. Cuba. Fax: (537)-210135; Internet: organ@infomed.sld.cu
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Publication Date:
31 December 2000 (online)

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An efficient and rapid method for the synthesis of 2-substituted 2-oxazolines by a direct method of simple cyclodehydration of a carboxylic acid and a β-aminoalcohol under microwave irradiation was devised.

2-substituted 2-oxazolines - microwave activation - tandem condensation-cyclodehydration