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Synthesis 1997; 1997(12): 1384-1386
DOI: 10.1055/s-1997-1381
short paper
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Synthesis of Linear and Angular Benzofurocoumarins

Carmen Terán1 , Rocio Miranda2 , Lourdes Santana2 , Marta Teijeira2 , Eugenio Uriarte3
  • 1Departamento de Química Física y Química Orgánica, Universidad de Vigo, Spain
  • 2Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
  • 3Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain, Fax +34(81)594912; E-mail: qofuri@usc.es
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Publication Date:
31 December 2000 (online)

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A four-step synthetic approach to substituted linear and angular benzofurocoumarins is described. Starting from 5-methoxyresorcinol, this approach afforded good yields of benzopsoralen (7), benzoangelicine (8), and benzoallopsoralen (11), which bear easily hydrolysed methoxy groups and thus allow access to other substituted compounds with potential as photochemotherapeutic agents.

Starting from 5-methoxyresorcinol, benzopsoralen, benzoangelicine and benzoallopsoralen were prepared via the corresponding coumarins and tetrahydrobenzofurocoumarins