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Synlett 1997; 1997(11): 1241-1242
DOI: 10.1055/s-1997-1553
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N-Bromosuccinimide as a Regioselective Nuclear Monobrominating Reagent for Phenols and Naphthols

M. Carmen Carreño1 , José L. García Ruano2 , Gema Sanz, Miguel A. Toledo, Antonio Urbano
  • 1Departamento de Química Orgánica (C-I), Universidad Autónoma, Cantoblanco, 28049-Madrid, SPAIN, Fax 34-1-397-3966; carmen.carrenno@uam.es
  • 2Departamento de Química Orgánica (C-I), Universidad Autónoma, Cantoblanco, 28049-Madrid, SPAIN, Fax 34-1-397-3966
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Publication History

Publication Date:
31 December 2000 (online)

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A wide range of substituted phenols and naphthols were regioselectively monobrominated with N-bromosuccinimide, at para position in acetonitrile and at ortho position in carbon disulfide, under mild conditions in good yields. Methylphenols afforded only nuclear bromination products.

regioselectivity - phenols - naphthols - bromination - NBS