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Synlett 1997; 1997(5): 587-588
DOI: 10.1055/s-1997-3234
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Unique Reactivity of Aminoketones in the Trifluoromethylation with Trialkyl(trifluoromethyl)silanes

Toshiki Hagiwara, Hiroaki Mochizuki, Takamasa Fuchikami*
  • *Sagami Chemical Research Center, Nishi-Ohnuma 4-4-1, Sagamihara, Kanagawa 229, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Aminoketones were trifluoromethylated by using trialkyl(trifluoromethyl)silanes without any reaction promoters. Formation of cyclic intermediates is proposed to be possible transition states in this reaction. Moderate diastereoselectivities were observed in the trifluoromethylation of the aminoketones having a side chain.

trifluoromethylation - aminoketones - (trifluoromethyl)silanes - diastereoselectivity