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Synlett 1997; 1997(6): 691-692
DOI: 10.1055/s-1997-3246
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Enantioselective Synthesis of γ-Hydroxynorvaline

M. Jacob, M. L. Roumestant* , P. Viallefont, J. Martinez
  • *Laboratoire des Aminoacides, Peptides et Proteines, ESA CNRS 5075, Université Montpellier I & II, 2, Place E. Bataillon, 34095 Montpellier Cedex 05, France, Fax (33) 04 67144866; roumestant@crit.univ-montp2.fr
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Publication Date:
31 December 2000 (online)

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A new synthesis of enantiomerically pure γ-hydroxynorvaline is described. The key step involves diastereoselective alkylation of the chiral Schiff base 1 with primary iodo derivatives 2 easily prepared from propylene oxide.

γ-hydroxynorvaline - alkylation - 2-hydroxypinan-3-one - epoxide