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Synlett 1997; 1997(6): 713-715
DOI: 10.1055/s-1997-3257
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Synthesis of Okadaic Acid-Tautomycin Hybrid

Katsunori Tsuboi, Yoshiyasu Ichikawa, Minoru Isobe*
  • *Laboratory of Organic Chemistry, School of Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-01, Japan, Fax +81-52-789-4111
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Publication History

Publication Date:
31 December 2000 (online)

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One of the three spiro-segments in the synthesis of okadaic acid was synthesized under a new heteroconjugate addition strategy. Successive coupling of this spiro-segment with two tautomycin-synthetic segments afforded a hybrid molecule between okadaic acid and tautomycin.

hybrid molecule - okadaic acid - tautomycin - protein phosphatase inhibitor - AB segment of TTM - C segment of OKA